鼻病毒诱发喘息加重后儿童鼻病毒的反复检测：一项回顾性研究。
Recurrent rhinovirus detections in children following a rhinovirus-induced wheezing exacerbation: A retrospective study.
作者信息
Halmø Hürdum Sofie, Zhang Guicheng, Khoo Siew-Kim, Bizzintino Joelene, Franks Kimberley Marie, Lindsay Katie, Keil Anthony David, Cox Desmond William, Goldblatt Jack, Bochkov Yury Alexandrovich, Gern James, Ulrik Charlotte Suppli, Souëf Peter Neils Le, Laing Ingrid Alisa
机构信息
School of Paediatrics and Child Health, The University of Western Australia, GPO Box D184, Perth, Western Australia, 6840, Australia; Department of Pulmonary Medicine, Hvidovre Hospital, University of Copenhagen, Kettegård Allé 30, 2650 Hvidovre, Denmark.
School of Paediatrics and Child Health, The University of Western Australia, GPO Box D184, Perth, Western Australia, 6840, Australia; School of Public Health, Curtin University, GPO Box U1987, Perth, Western Australia, 6845, Australia.
出版信息
Int J Pediatr Child Health. 2015 Aug;3(1):10-18. doi: 10.12974/2311-8687.2015.03.01.2.
INTRODUCTION
It is unclear if children with a rhinovirus (RV)-induced wheezing exacerbation are more susceptible to viruses longitudinally, and whether a parental history of asthma and/or allergy impacts their susceptibility. The objective of this study was to determine if RV, RV-A and RV-C related wheezing exacerbations in children were associated with prior or subsequent viral detections and investigate the role of parental history of asthma and allergy.
MATERIALS AND METHODS
Children presenting to hospital with acute wheeze were prospectively recruited and tested for respiratory viruses. Data on viruses detected in other respiratory samples (May 1997 to December 2012) were collected from hospital microbiology records and additional RV testing was performed on stored hospital respiratory samples (September 2009 to December 2012). A positive parental history was defined as either parent with self-reported asthma and/or allergy.
RESULTS
At recruitment, RV was detected in 69.2% of samples from children with an acute wheezing episode (n=373, 0-16 years of age), with RV-C the most common virus (65.5%). Children with a history of parental asthma and/or allergy and RV at recruitment had a 14-fold increased incidence rate ratio (IRR) of subsequent RV detection (IRR 14.0, 95% CI 1.9-104.1; p=0.01) compared with children without RV at recruitment. Children without this parental history had a reduced incident rate ratio for samples assessed during this time (IRR 0.5, 95% CI 0.3-0.9; p=0.03).
CONCLUSION
Children with a parental history of asthma and/or allergy may become more susceptible to recurrent symptomatic RV infections.
引言
目前尚不清楚因鼻病毒（RV）诱发喘息加重的儿童在纵向层面上是否更容易感染病毒，以及父母的哮喘和/或过敏病史是否会影响他们的易感性。本研究的目的是确定儿童中与RV、RV - A和RV - C相关的喘息加重是否与之前或之后的病毒检测有关，并调查父母哮喘和过敏病史的作用。
材料与方法
前瞻性招募因急性喘息到医院就诊的儿童，并对其进行呼吸道病毒检测。从医院微生物记录中收集其他呼吸道样本（1997年5月至2012年12月）中检测到的病毒数据，并对储存的医院呼吸道样本（2009年9月至2012年12月）进行额外的RV检测。阳性家族史定义为父母一方有自我报告的哮喘和/或过敏。
结果
在招募时，急性喘息发作儿童的样本中69.2%检测到RV（n = 373，0 - 16岁），其中RV - C是最常见的病毒（65.5%）。招募时患有父母哮喘和/或过敏病史且检测到RV的儿童，与招募时未检测到RV的儿童相比，后续RV检测的发病率比（IRR）增加了14倍（IRR 14.0，95% CI 1.9 - 104.1；p = 0.01）。没有这种家族史的儿童在此期间评估的样本发病率比降低（IRR 0.5，95% CI 0.3 - 0.9；p = 0.03）。
结论
有父母哮喘和/或过敏病史的儿童可能更容易反复发生有症状的RV感染。
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