在 COVID-19 大流行之前，对儿童<2 岁毛细支气管炎常见呼吸道病毒流行率的系统评价和荟萃分析。
Systematic review and meta-analysis of the prevalence of common respiratory viruses in children < 2 years with bronchiolitis in the pre-COVID-19 pandemic era.
机构信息
Department of Virology, Centre Pasteur of Cameroon, Yaoundé, Cameroon.
National AIDS Control Committee, Epidemiological Surveillance, Evaluation and Research Unit, Yaounde, Cameroon.
出版信息
PLoS One. 2020 Nov 12;15(11):e0242302. doi: 10.1371/journal.pone.0242302. eCollection 2020.
INTRODUCTION
The advent of genome amplification assays has allowed description of new respiratory viruses and to reconsider the role played by certain respiratory viruses in bronchiolitis. This systematic review and meta-analysis was initiated to clarify the prevalence of respiratory viruses in children with bronchiolitis in the pre-COVID-19 pandemic era.
METHODS
We performed an electronic search through Pubmed and Global Index Medicus databases. We included observational studies reporting the detection rate of common respiratory viruses in children with bronchiolitis using molecular assays. Data was extracted and the quality of the included articles was assessed. We conducted sensitivity, subgroups, publication bias, and heterogeneity analyses using a random effect model.
RESULTS
The final meta-analysis included 51 studies. Human respiratory syncytial virus (HRSV) was largely the most commonly detected virus 59.2%; 95% CI [54.7; 63.6]). The second predominant virus was Rhinovirus (RV) 19.3%; 95% CI [16.7; 22.0]) followed by Human bocavirus (HBoV) 8.2%; 95% CI [5.7; 11.2]). Other reported viruses included Human Adenovirus (HAdV) 6.1%; 95% CI [4.4; 8.0]), Human Metapneumovirus (HMPV) 5.4%; 95% CI [4.4; 6.4]), Human Parainfluenzavirus (HPIV) 5.4%; 95% CI [3.8; 7.3]), Influenza 3.2%; 95% CI [2.2; 4.3], Human Coronavirus (HCoV) 2.9%; 95% CI [2.0; 4.0]), and Enterovirus (EV) 2.9%; 95% CI [1.6; 4.5]). HRSV was the predominant virus involved in multiple detection and most codetections were HRSV + RV 7.1%, 95% CI [4.6; 9.9]) and HRSV + HBoV 4.5%, 95% CI [2.4; 7.3]).
CONCLUSIONS
The present study has shown that HRSV is the main cause of bronchiolitis in children, we also have Rhinovirus, and Bocavirus which also play a significant role. Data on the role played by SARS-CoV-2 in children with acute bronchiolitis is needed.
REVIEW REGISTRATION
PROSPERO, CRD42018116067.
简介
基因组扩增检测方法的出现使人们能够描述新的呼吸道病毒，并重新考虑某些呼吸道病毒在细支气管炎中的作用。本系统评价和荟萃分析旨在阐明 COVID-19 大流行前细支气管炎患儿中常见呼吸道病毒的流行情况。
方法
我们通过 Pubmed 和全球索引医学数据库进行了电子检索。我们纳入了使用分子检测方法报告儿童细支气管炎中常见呼吸道病毒检出率的观察性研究。提取数据并评估纳入文章的质量。我们使用随机效应模型进行了敏感性、亚组、发表偏倚和异质性分析。
结果
最终的荟萃分析纳入了 51 项研究。人呼吸道合胞病毒（HRSV）是最常见的病毒，检出率为 59.2%；95%CI[54.7；63.6%]）。第二大常见病毒是鼻病毒（RV），检出率为 19.3%；95%CI[16.7；22.0%]），其次是人类博卡病毒（HBoV），检出率为 8.2%；95%CI[5.7；11.2%]）。其他报告的病毒包括人类腺病毒（HAdV），检出率为 6.1%；95%CI[4.4；8.0%]）、人偏肺病毒（HMPV），检出率为 5.4%；95%CI[4.4；6.4%]）、人类副流感病毒（HPIV），检出率为 5.4%；95%CI[3.8；7.3%]）、流感病毒，检出率为 3.2%；95%CI[2.2；4.3%]）、人类冠状病毒（HCoV），检出率为 2.9%；95%CI[2.0；4.0%]）和肠道病毒（EV），检出率为 2.9%；95%CI[1.6；4.5%]）。HRSV 是多种检测中主要涉及的病毒，大多数共检测到的病毒是 HRSV+RV，检出率为 7.1%；95%CI[4.6；9.9%]）和 HRSV+HBoV，检出率为 4.5%；95%CI[2.4；7.3%]）。
结论
本研究表明，HRSV 是儿童细支气管炎的主要病因，我们还发现了鼻病毒和博卡病毒也有重要作用。需要研究 SARS-CoV-2 在急性细支气管炎患儿中的作用。
审查登记
PROSPERO，CRD42018116067。
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