Garruto R M, Plato C C, Yanagihara R, Fox K, Dutt J, Gajdusek D C, Tobin J
Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892.
Am J Phys Anthropol. 1989 Sep;80(1):107-13. doi: 10.1002/ajpa.1330800112.
Bone mass, as assessed by measurements of total subperiosteal diameter and medullary width of the second metacarpal bone on hand-wrist radiographs, was evaluated for 31 Guamanian patients (15 males, 16 females) with amyotrophic lateral sclerosis (ALS), 67 patients (39 males, 28 females) with parkinsonism-dementia (PD), and 66 (34 males, 32 females) nonaffected Guamanian controls. Comparisons between the two disease groups and between each disease group and the nonaffected controls were made taking into account the sex, age, and disability status of each participant. At all ages, ALS patients of both sexes had significantly lower percent cortical areas (PCA) than did nonaffected controls. The ALS males also had significantly lower PCA than PD males, although no significant differences were observed between female ALS and PD patients. The PD patients of either sex had a lower PCA when compared to controls, but the differences were not statistically significant. The observed differences in PCA were due solely to increased medullary width, suggesting that the diminished cortical bone thickness resulted from greater bone resorption rather than differential bone growth. Longitudinal studies support the cross-sectional findings of accelerated bone loss among ALS patients. It is not possible to determine from the present data whether the observed differences in PCA of the second metacarpal of the ALS patients are due to atrophy of the first interosseous muscle, to a generalized resorption process inherently associated with the development and progression of ALS, or to factors not accounted for by the present analysis.
通过对手腕部X光片上第二掌骨的总骨膜下直径和髓腔宽度进行测量来评估骨量，对31名患有肌萎缩侧索硬化症（ALS）的关岛患者（15名男性，16名女性）、67名患有帕金森病痴呆症（PD）的患者（39名男性，28名女性）以及66名未受影响的关岛对照者（34名男性，32名女性）进行了评估。在考虑每个参与者的性别、年龄和残疾状况的情况下，对两个疾病组之间以及每个疾病组与未受影响的对照组之间进行了比较。在所有年龄段，两性的ALS患者的皮质面积百分比（PCA）均显著低于未受影响的对照组。ALS男性的PCA也显著低于PD男性，尽管女性ALS和PD患者之间未观察到显著差异。与对照组相比，两性的PD患者的PCA较低，但差异无统计学意义。观察到的PCA差异完全是由于髓腔宽度增加，这表明皮质骨厚度的减少是由于更大的骨吸收而不是不同的骨生长。纵向研究支持了ALS患者骨量加速流失的横断面研究结果。根据目前的数据，无法确定ALS患者第二掌骨PCA的观察差异是由于第一骨间肌萎缩、与ALS的发生和发展固有相关的全身性吸收过程，还是由于本分析未考虑的因素。
