Dasgupta Romi, Chatterjee Aniruddha, Sarkar Supriti, Maiti B R
a Department of Zoology , University of Calcutta , Calcutta , India.
b Scottish Church College , Calcutta , India , and.
Arch Physiol Biochem. 2017 May;123(2):105-111. doi: 10.1080/13813455.2016.1267228. Epub 2016 Dec 26.
Millions of people consume betel nut for increased capacity of work. It contains arecoline which is highly toxic and has several untoward side effects on endocrine functions. In this article, the role of arecoline on thyroid function under metabolic stress was investigated in mice. Water or food-deprivation, each for 5 days, caused ultrastructural degeneration of thyro-follicular cells, evident from pycnotic nuclei, scanty rough endoplasmic reticulum and mitochondria followed by depletion of blood serum T and T levels with alteration of TSH level as compared with control. Thyroid activity was also suppressed ultrastructurally as well as at hormonal level after arecoline administration. Further, arecoline treatment in water deprivation or food deprivation stress also caused thyroid dysfunction beyond that of metabolic stress, as evident from further ultrastructural degeneration of thyrocytes and depletion of thyroid hormones in mice. The findings suggest that arecoline aggravates hypothyroid condition in metabolic stress in mice.
数百万人食用槟榔以提高工作能力。槟榔含有槟榔碱，其毒性很强，对内分泌功能有多种不良副作用。在本文中，研究了槟榔碱在代谢应激状态下对小鼠甲状腺功能的作用。禁食水或食物5天，均导致甲状腺滤泡细胞超微结构退化，表现为细胞核固缩、粗面内质网和线粒体稀少，随后血清T和T水平降低，促甲状腺激素（TSH）水平与对照组相比发生改变。给予槟榔碱后，甲状腺活性在超微结构和激素水平上也受到抑制。此外，在禁食水或食物应激状态下给予槟榔碱治疗，小鼠甲状腺功能障碍比单纯代谢应激更严重，表现为甲状腺细胞进一步超微结构退化和甲状腺激素减少。研究结果表明，槟榔碱会加重小鼠代谢应激状态下的甲状腺功能减退状况。
