Department of Zoology, University of Calcutta, Calcutta, India.
Arch Physiol Biochem. 2020 Feb;126(1):7-16. doi: 10.1080/13813455.2018.1486428. Epub 2018 Aug 25.
Arecoline is known to cause endocrine dysfunction. In the current article role of arecoline on pineal-testis activity was investigated in hypothyroid rats induced by propylthiouracil (PTU). PTU treatment caused thyroid dysfunction ultrastructurally with a fall in T and T levels followed by a rise of thyroid stimulating hormone (TSH) level. Pineal activity was impaired by PTU treatment, as evident from degenerated synaptic ribbons and mitochondria of the pinealocytes with depletion of pineal and serum -acetyl serotonin and melatonin levels. Leydig cell function was suppressed, evident from reduced smooth endoplasmic reticulum and depletion of testosterone level. Sex accessories function was impaired by showing scanty rough endoplasmic reticulum with depletion of fructose and sialic acid levels. Arecoline treatment that caused pineal dysfunction and testicular stimulation in control rats, suppressed both pineal and testis functions after PTU treatment. The findings suggest that arecoline inhibits pineal-testis function in experimentally induced hypothyroid rats.
槟榔碱已知会导致内分泌功能紊乱。在目前的文章中，研究了槟榔碱对丙基硫氧嘧啶（PTU）诱导的甲状腺功能减退大鼠松果体-睾丸活性的作用。PTU 处理导致甲状腺功能超微结构异常，T 和 T 水平下降，随后促甲状腺激素（TSH）水平升高。松果体活动因 PTU 处理而受损，这从松果体细胞的退化突触带和线粒体中显而易见，伴随着松果体和血清 -乙酰血清素和褪黑素水平的耗竭。Leydig 细胞功能受到抑制，这从减少的光滑内质网和睾酮水平的耗竭中显而易见。性附件功能受损，表现为粗面内质网减少，果糖和唾液酸水平耗竭。槟榔碱处理在对照大鼠中引起松果体功能障碍和睾丸刺激，在 PTU 处理后抑制了松果体和睾丸功能。这些发现表明，槟榔碱抑制实验性诱导的甲状腺功能减退大鼠的松果体-睾丸功能。
