马兜铃根茎中的四种新化合物。

Four new compounds from the rhizome of Aristolochia championii.

作者信息

Wang Xin, Shi Guo-Ru, Liu Yan-Fei, Chen Ruo-Yun, Yu De-Quan

机构信息

a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.

出版信息

J Asian Nat Prod Res. 2017 Feb;19(2):114-120. doi: 10.1080/10286020.2016.1268129. Epub 2016 Dec 25.

DOI:10.1080/10286020.2016.1268129

PMID:28019104

Abstract

Three new flavonoid glycosides (1-3) and one new aristololactam N-glycoside (4) were isolated from the rhizome of Aristolochia championii. The structures of compounds 1-4 were elucidated on the basis of their spectroscopic data and chemical evidence (UV, IR, HR-ESI-MS, 1D and 2D NMR). Their structures were determined as 8-(5-formyl-2-furanmethyl)-isorhamentin 3-O-robinobioside (1), 8-(5-methyl-2-furanoyl)-isorhamentin 3-O-robinobioside (2), 8-formylisorhamentin 3-O-robinobioside (3), and N-β-D-glucopyranosylaristololactam V (4), respectively.

摘要

从马兜铃的根茎中分离出三种新的黄酮苷（1-3）和一种新的马兜铃内酰胺N-苷（4）。根据化合物1-4的光谱数据和化学证据（紫外光谱、红外光谱、高分辨电喷雾电离质谱、一维和二维核磁共振）阐明了它们的结构。它们的结构分别确定为8-(5-甲酰基-2-呋喃甲基)-异鼠李素3-O-刺槐二糖（1）、8-(5-甲基-2-呋喃甲酰基)-异鼠李素3-O-刺槐二糖（2）、8-甲酰基异鼠李素3-O-刺槐二糖（3）和N-β-D-吡喃葡萄糖基马兜铃内酰胺V（4）。