Wang Xin, Shi Guo-Ru, Liu Yan-Fei, Li Li, Chen Ruo-Yun, Yu De-Quan
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Fitoterapia. 2017 Apr;118:63-68. doi: 10.1016/j.fitote.2017.01.006. Epub 2017 Jan 27.
Four new aristolochic acid derivatives aristchamic A (1), aristchamic B (2), aristochamic C (3a), aristchamic D (3b) and one new aristolactam aristolactam-CV (4), together with 10 known compounds (5-14), were isolated from the rhizomes of Aristolochia championii. Their structures were assigned by detailed analysis of MS and NMR spectroscopic data. All of the isolated compounds were evaluated for their cytotoxic activities against HCT-116, HepG2, BGC-823, NCI-H1650, and A2780 cell. Compound 1 exhibited significant cytotoxic activity against HCT-116, HepG2, BGC-823, and NCI-H1650, with IC values of 0.50, 7.37, 2.66, and 0.75μM, respectively.
从马兜铃的根茎中分离出四种新的马兜铃酸衍生物马兜铃酰胺A（1）、马兜铃酰胺B（2）、马兜铃酰胺C（3a）、马兜铃酰胺D（3b）和一种新的马兜铃内酰胺马兜铃内酰胺-CV（4），以及10种已知化合物（5-14）。通过对质谱和核磁共振光谱数据的详细分析确定了它们的结构。对所有分离出的化合物进行了针对HCT-116、HepG2、BGC-823、NCI-H1650和A2780细胞的细胞毒性活性评估。化合物1对HCT-116、HepG2、BGC-823和NCI-H1650表现出显著的细胞毒性活性，其IC值分别为0.50、7.37、2.66和0.75μM。
