Massaro G D, Olivier J, Massaro D
Calvin and Flavia Oak Asthma Research and Treatment Facility, University of Miami School of Medicine 33136.
Am J Physiol. 1989 Oct;257(4 Pt 1):L221-5. doi: 10.1152/ajplung.1989.257.4.L221.
We studied the effect of breathing 10% O2 for less than or equal to 9 h by rat dams during the last day of gestation and (with their pups) for 1-2 h immediately after birth on the development of the lung's gas exchange region in the pups. Our major finding is that this brief stress resulted in substantially altered lung development noted at age 7 days and still partially present at age 30 days. In particular, perinatal hypoxia slowed the postnatal increase of lung volume, delayed septation of the large gas exchange saccules, diminished the increase of the gas exchange surface area, but accelerated thinning of the wall of the gas exchange structures. The changes produced by briefly breathing 10% O2 had as great an effect on these aspects of lung development as the same prenatal exposure to 10% O2 plus continuous postnatal exposure to 10% O2 for 7 days. Breathing 10% O2 had a particularly strong effect on alveolar wall thinning, since 2 h of breathing 10% O2 immediately after birth, without prenatal hypoxia, accelerated thinning of the alveolar wall.
我们研究了妊娠最后一天母鼠呼吸10%氧气持续时间小于或等于9小时以及（与它们的幼崽一起）出生后立即呼吸1-2小时对幼崽肺气体交换区域发育的影响。我们的主要发现是，这种短暂的应激导致7日龄时肺发育明显改变，且在30日龄时仍部分存在。特别是，围产期缺氧减缓了出生后肺体积的增加，延迟了大型气体交换囊泡的分隔，减少了气体交换表面积的增加，但加速了气体交换结构壁的变薄。短暂呼吸10%氧气所产生的变化对肺发育的这些方面的影响，与产前同样暴露于10%氧气加上出生后持续7天暴露于10%氧气的影响一样大。呼吸10%氧气对肺泡壁变薄有特别强烈的影响，因为出生后立即呼吸10%氧气2小时，在没有产前缺氧的情况下，加速了肺泡壁的变薄。
