Held-Munzenmaier D, Olinger G N, Boerboom L E
Department of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee 53226.
Am J Physiol. 1989 Oct;257(4 Pt 2):H1312-4. doi: 10.1152/ajpheart.1989.257.4.H1312.
Implantation of micromanometer-tipped catheters into dogs and other animals for invasive high-fidelity blood pressure measurement is expensive and impractical. We have devised an implantable sheath that allows insertion of the transducer each time the animal is to be studied. This eliminates animal-inflicted damage and the need for multiple transducers if several animals are to be instrumented concurrently. The sheath is coextruded from hard and soft forms of polyurethane to form a soft, flexible, thrombus-resistant tubing with a hard thin inner lining having a low coefficient of friction. This allows chronic implantation of the sheath into the heart and major vessels with minimal trauma, yet enables a transducer to be advanced through a sheath only slightly larger than the transducer itself without the frictional resistance common to other soft tubing. The sheath can be tapered for ease of implantation into vessels or curved to the appropriate angle for implantation into the heart. Our polyurethane sheath is a versatile, convenient, and inexpensive alternative to chronic instrumentation with transducers for high-fidelity pressure measurement.
将带有微压计的导管植入狗和其他动物体内以进行有创高保真血压测量既昂贵又不切实际。我们设计了一种可植入的护套，每次对动物进行研究时都能插入换能器。这样可以消除动物造成的损伤，并且如果要同时对几只动物进行监测，就无需使用多个换能器。该护套由硬质和软质聚氨酯共挤出而成，形成一种柔软、灵活、抗血栓的管道，其坚硬的薄内衬具有低摩擦系数。这使得护套能够以最小的创伤长期植入心脏和大血管，同时能让换能器穿过仅比其自身略大一点的护套，而不会产生其他软质管道常见的摩擦阻力。护套可以做成锥形以便于植入血管，或者弯曲到合适的角度以便于植入心脏。我们的聚氨酯护套是用于高保真压力测量的换能器长期监测的一种通用、便捷且廉价的替代方案。
