Van Tassel R A, Gobel F L, Rydell M A, Vlodaver Z, MacCarter D J
Cathet Cardiovasc Diagn. 1985;11(2):187-99. doi: 10.1002/ccd.1810110211.
A deformable soft-tipped angiographic catheter has been designed and developed to reduce vascular trauma during coronary arteriography. In order to test the ability of the catheter tip glide over vascular endothelium, the coefficient of resistance was tested using fresh human aortic tissue. The mean frictional coefficients of resistance (FRc) for the soft-tipped catheter, as compared with two commonly used catheters (N = 10/group), were .78 +/- .08 units for the soft-tipped catheter and 1.10 +/- .10 (p less than .006) and .98 +/- .10 (p less than .034) for the conventional catheters. This demonstrates a significant 23% reduction in FRc with the soft-tipped catheter. The ease of penetration into a wax media was also measured using the soft-tipped catheter and compared with the same two conventional catheters. The indentation depths for the soft-tipped catheter and the two other catheter groups (N = 7/group) were 140 +/- 18 micron, 246 +/- 15 micron and 318 +/- 20 micron, respectively. This represents a 56% decrease in indentation depth with the soft-tipped catheter. Histologic studies in canines have demonstrated considerably less endothelial damage and subsequent intimal proliferation in the aorta and coronary ostia with the soft-tipped catheters compared with control catheters. It is concluded that a soft-tipped angiographic catheter is less traumatic to vascular tissue and may offer a safer approach to intravascular studies.
一种可变形的软头血管造影导管已被设计和开发出来，以减少冠状动脉造影过程中的血管创伤。为了测试导管尖端在血管内皮上滑动的能力，使用新鲜的人体主动脉组织对阻力系数进行了测试。与两种常用导管相比（每组N = 10），软头导管的平均摩擦阻力系数（FRc）为0.78±0.08单位，传统导管的平均摩擦阻力系数分别为1.10±0.10（p < 0.006）和0.98±0.10（p < 0.034）。这表明软头导管的FRc显著降低了23%。还使用软头导管测量了其穿透蜡介质的难易程度，并与相同的两种传统导管进行了比较。软头导管组和其他两组导管（每组N = 7）的压痕深度分别为140±18微米、246±15微米和318±20微米。这表明软头导管的压痕深度减少了56%。犬类的组织学研究表明，与对照导管相比，软头导管对主动脉和冠状动脉口的内皮损伤及随后的内膜增生要少得多。结论是，软头血管造影导管对血管组织的创伤较小，可能为血管内研究提供一种更安全的方法。
