Flynn R J, Moore J, Collier P S, Howard P J
Department of Anaesthetics, Queen's University of Belfast, Northern Ireland.
Anaesthesia. 1989 Sep;44(9):739-41. doi: 10.1111/j.1365-2044.1989.tb09259.x.
We studied whether an intravenous bolus of cimetidine altered the disposition of extradurally administered lignocaine in the parturient. Mothers who requested extradural analgesia for elective Caesarean section were randomly pretreated with either cimetidine 200 mg intravenously (n = 5) or no H2-receptor antagonist (n = 5). No difference was found between peak plasma lignocaine levels or area under the plasma concentration/time curve between the two groups after administration of 6 mg/kg lignocaine 2% with adrenaline 1:200,000. There was no evidence for an effect of a single intravenous dose of cimetidine on lignocaine disposition in the obstetric patient. In addition, the extradural administration of 6 mg/kg lignocaine produces plasma levels well below toxic levels.
我们研究了静脉推注西咪替丁是否会改变硬膜外给予利多卡因在产妇体内的处置情况。因择期剖宫产而要求硬膜外镇痛的产妇被随机预先给予静脉注射200毫克西咪替丁（n = 5）或不给予H2受体拮抗剂（n = 5）。在给予含1:200,000肾上腺素的2%利多卡因6毫克/千克后，两组之间的血浆利多卡因峰值水平或血浆浓度/时间曲线下面积没有差异。没有证据表明单次静脉注射西咪替丁对产科患者体内利多卡因的处置有影响。此外，硬膜外给予6毫克/千克利多卡因所产生的血浆水平远低于中毒水平。
