Flynn R J, Moore J, Collier P S, Howard P J
Department of Anaesthetics, Queen's University of Belfast, Northern Ireland, UK.
Acta Anaesthesiol Scand. 1989 Oct;33(7):593-6. doi: 10.1111/j.1399-6576.1989.tb02973.x.
We studied whether a single oral dose of either cimetidine or ranitidine affects the disposition of epidurally administered lidocaine in the parturient. Patients given epidural analgesia for elective caesarean section were randomly pretreated with either cimetidine 400 mg (n = 5), ranitidine 150 mg (n = 7) or no H2 receptor antagonist (n = 5). Following the administration of 400 mg of lidocaine 2% with adrenaline 1:200,000 no difference was found in peak plasma lidocaine levels or area under the plasma concentration/time curve (AUC) between the three groups. A single oral dose of cimetidine or ranitidine does not affect lidocaine disposition in the obstetric patient.
我们研究了单次口服西咪替丁或雷尼替丁是否会影响硬膜外给予利多卡因在产妇体内的处置。因择期剖宫产接受硬膜外镇痛的患者被随机预先给予西咪替丁400mg（n = 5）、雷尼替丁150mg（n = 7）或不给予H2受体拮抗剂（n = 5）。在给予含1:200,000肾上腺素的2%利多卡因400mg后，三组之间的血浆利多卡因峰值水平或血浆浓度/时间曲线下面积（AUC）未发现差异。单次口服西咪替丁或雷尼替丁不影响产科患者体内利多卡因的处置。
