Fink S W, Freas R B
Anal Chem. 1989 Sep 15;61(18):2050-4. doi: 10.1021/ac00193a010.
The effects of a needle-tip repeller electrode on thermospray mass spectra of poly(ethylene glycols) and peptide samples have been studied. A significant increase in ion current was observed for increased repeller potentials in the low-mass region (m/z 300 to m/z 1100) and the high-mass region (m/z 1100 to m/z 1900). The change in ion current is due to a change in ion extraction efficiency because of increased ion diffusion rates. The amount of peptide sample needed for direct injection studies was decreased 1 to 2 orders of magnitude by using an ion source with both a needle-tip repeller electrode and a restricted vaporizer probe tip.
研究了针尖排斥电极对聚乙二醇和肽样品热喷雾质谱的影响。在低质量区（m/z 300至m/z 1100）和高质量区（m/z 1100至m/z 1900），随着排斥电位的增加，离子电流显著增加。离子电流的变化是由于离子扩散速率增加导致离子提取效率发生变化。通过使用带有针尖排斥电极和受限蒸发器探头尖端的离子源，直接进样研究所需的肽样品量减少了1至2个数量级。
