Law S C, Ramzan I M, Brandom B W, Cook D R
Department of Anesthesiology, University of Pittsburgh School of Medicine, Pennsylvania.
Anesth Analg. 1989 Nov;69(5):611-3.
The neuromuscular action of ranitidine, an H2-receptor antagonist, was investigated by determining its effect on atracurium-induced neuromuscular blockade in urethane-anesthetized and mechanically ventilated male Sprague-Dawley rats. An intravenous bolus and an infusion of atracurium were administered to produce a stable 93 +/- 5% (n = 11) neuromuscular blockade as judged by tibialis anterior muscle twitch response. Ranitidine administered as a 1, 5, or 10 mg/kg normal body weight IV bolus during continuous atracurium infusion produced marked antagonism of neuromuscular paralysis. The percentage of antagonism (25 +/- 9%; n = 4; 53 +/- 19%, n = 4; and 79 +/- 9%, n = 3, respectively) was linearly related to the dose of ranitidine (r = 0.86, P less than 0.05). These results suggest that IV ranitidine has a significant anticholinesterase action against atracurium-induced neuromuscular blockade.
通过测定雷尼替丁（一种H2受体拮抗剂）对氨基甲酸乙酯麻醉并机械通气的雄性Sprague-Dawley大鼠中阿曲库铵诱导的神经肌肉阻滞的影响，研究了雷尼替丁的神经肌肉作用。静脉注射大剂量阿曲库铵并持续输注，以使胫前肌抽搐反应判定的神经肌肉阻滞稳定在93±5%（n = 11）。在持续输注阿曲库铵期间，以1、5或10 mg/kg正常体重静脉推注雷尼替丁，可显著拮抗神经肌肉麻痹。拮抗百分比（分别为25±9%，n = 4；53±19%，n = 4；79±9%，n = 3）与雷尼替丁剂量呈线性相关（r = 0.86，P < 0.05）。这些结果表明，静脉注射雷尼替丁对阿曲库铵诱导的神经肌肉阻滞具有显著的抗胆碱酯酶作用。
