Fu C, Mishra Y, Ramzan I
Department of Pharmacy, University of Sydney, New South Wales, Australia.
Anesth Analg. 1994 Mar;78(3):527-30. doi: 10.1213/00000539-199403000-00019.
We examined the effect of proton pump inhibitor omeprazole on neuromuscular paralysis induced with either nondepolarizing or depolarizing neuromuscular blocking drugs in anesthetized and mechanically ventilated rats. Neuromuscular paralysis, as judged by tibialis anterior muscle twitch tension in response to sciatic nerve stimulation, was maintained at about 50% with intravenous (i.v.) bolus and infusion regimens of either atracurium or succinylcholine. Omeprazole, 0.5, 1, and 10 mg/kg i.v., was then administered at 10-min intervals while the infusion of the neuromuscular blocker was continued. Omeprazole at all three doses increased the steady-state neuromuscular paralysis produced with either atracurium (pre-omeprazole versus final post-omeprazole paralysis; mean +/- SE, n = 6, 53.0% +/- 2.3% vs 80.0% +/- 5.3%) or succinylcholine (50.8% +/- 1.5% vs 86.4% +/- 5.1%). Omeprazole, 0.5, 1.0, and 10 mg/kg i.v., given directly and without any neuromuscular blocker, produced approximately 5% depression of the muscle twitch response. Omeprazole, i.v. at human therapeutic doses, alters neuromuscular function and enhances the action of both atracurium and succinylcholine in vivo in rats.
我们研究了质子泵抑制剂奥美拉唑对麻醉并机械通气大鼠使用非去极化或去极化神经肌肉阻滞剂所致神经肌肉麻痹的影响。通过刺激坐骨神经后胫前肌的抽搐张力来判断神经肌肉麻痹情况，使用阿曲库铵或琥珀酰胆碱的静脉推注和输注方案可使神经肌肉麻痹维持在约50%。然后每隔10分钟静脉注射0.5、1和10mg/kg的奥美拉唑，同时继续输注神经肌肉阻滞剂。所有三种剂量的奥美拉唑均增加了由阿曲库铵（奥美拉唑给药前与最终给药后麻痹情况；均值±标准误，n = 6，53.0%±2.3% 对 80.0%±5.3%）或琥珀酰胆碱（50.8%±1.5% 对 86.4%±5.1%）产生的稳态神经肌肉麻痹。直接静脉注射0.5、1.0和10mg/kg的奥美拉唑且不使用任何神经肌肉阻滞剂，可使肌肉抽搐反应降低约5%。以人体治疗剂量静脉注射奥美拉唑会改变大鼠体内的神经肌肉功能，并增强阿曲库铵和琥珀酰胆碱的作用。
