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冠心病患者的粘弹性和红细胞聚集性

Viscoelasticity and red blood cell aggregation in patients with coronary heart disease.

作者信息

Hahn R, Müller-Seydlitz P M, Jöckel K H, Hubert H, Heimburg P

机构信息

Division of Cardiology, Robert-Bosch-Hospital, Stuttgart, West Germany.

出版信息

Angiology. 1989 Oct;40(10):914-20. doi: 10.1177/000331978904001010.

DOI:10.1177/000331978904001010
PMID:2802261
Abstract

Viscoelastic parameters were evaluated in 169 consecutive male patients with clinical signs of coronary heart disease. The patients were classified according to the extent of coronary artery stenosis. Levels of blood viscosity, erythrocyte aggregation, and plasma viscosity were elevated in patients with extensive coronary vessel disease. However, the differences between the several groups were not statistically significant. The increase of hemorheologic parameters was mainly due to high hematocrit, fibrinogen, and cholesterol concentrations. There was a significant correlation between plasma fibrinogen values and plasma viscosity levels. Blood viscosity and erythrocyte aggregation can be described by multiple linear regression as a function of the sum of log hematocrit, fibrinogen, cholesterol, and alpha 2-macroglobulin.

摘要

对169例有冠心病临床症状的连续男性患者进行了粘弹性参数评估。这些患者根据冠状动脉狭窄程度进行分类。在广泛冠状动脉疾病患者中,血液粘度、红细胞聚集和血浆粘度水平升高。然而,几组之间的差异无统计学意义。血液流变学参数的增加主要归因于高血细胞比容、纤维蛋白原和胆固醇浓度。血浆纤维蛋白原值与血浆粘度水平之间存在显著相关性。血液粘度和红细胞聚集可用多元线性回归描述为对数血细胞比容、纤维蛋白原、胆固醇和α2-巨球蛋白总和的函数。

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