异性和同性双胞胎的早期死亡风险：一项关于双胞胎睾酮转移假说的丹麦队列研究。
Early-life mortality risks in opposite-sex and same-sex twins: a Danish cohort study of the twin testosterone transfer hypothesis.
作者信息
Ahrenfeldt Linda Juel, Larsen Lisbeth Aagaard, Lindahl-Jacobsen Rune, Skytthe Axel, Hjelmborg Jacob V B, Möller Sören, Christensen Kaare
机构信息
Department of Public Health, The Danish Twin Registry, Unit of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense C, Denmark; Department of Public Health, Max-Planck Odense Center on the Biodemography of Aging, University of Southern Denmark, Odense C, Denmark.
Department of Public Health, The Danish Twin Registry, Unit of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense C, Denmark.
出版信息
Ann Epidemiol. 2017 Feb;27(2):115-120.e2. doi: 10.1016/j.annepidem.2016.11.011. Epub 2016 Dec 9.
PURPOSE
To investigate the twin testosterone transfer (TTT) hypothesis by comparing early-life mortality risks of opposite-sex (OS) and same-sex (SS) twins during the first 15 years of life.
METHODS
We performed a population-based cohort study to compare mortality in OS and SS twins. We included 68,629 live-born Danish twins from 1973 to 2009 identified through the Danish Twin Registry and performed piecewise stratified Cox regression and log-binomial regression.
RESULTS
Among 1933 deaths, we found significantly higher mortality for twin boys than for twin girls. For both sexes, OS twins had lower mortality than SS twins; the difference persisted for the first year of life for boys and for the first week of life for girls.
CONCLUSIONS
Although the mortality risk for OS boys was in the expected direction according to the TTT hypothesis, the results for OS girls pointed in the opposite direction, providing no clear evidence for the TTT hypothesis.
目的
通过比较异性（OS）和同性（SS）双胞胎在生命最初15年的早期死亡风险，来研究双胞胎睾酮转移（TTT）假说。
方法
我们进行了一项基于人群的队列研究，以比较OS和SS双胞胎的死亡率。我们纳入了1973年至2009年通过丹麦双胞胎登记处识别的68,629例丹麦活产双胞胎，并进行了分段分层Cox回归和对数二项回归。
结果
在1933例死亡病例中，我们发现双胞胎男孩的死亡率显著高于双胞胎女孩。对于两性而言，OS双胞胎的死亡率均低于SS双胞胎；这种差异在男孩出生后的第一年和女孩出生后的第一周持续存在。
结论
尽管根据TTT假说，OS男孩的死亡风险符合预期方向，但OS女孩的结果却指向相反方向，没有为TTT假说提供明确证据。
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