Lim G I, Koay E S, Aw T C
Clinical Chemistry Laboratory, National University Hospital.
Ann Acad Med Singap. 1989 Jul;18(4):357-62.
The measurement of glycosylated haemoglobin is a relatively new clinical tool, the assays for their determination having become increasingly available since their introduction in the late seventies. The clinical usefulness of these assays in the long-term monitoring of diabetics, especially the pregnant diabetics, appears to be generally accepted. There remains, however, considerable confusion amongst clinicians as to their reliability and interpretation. This is largely engendered by the diversity of the diagnostic methods in current usage, many of which are not specific for the HbA1c moiety, which is the subfraction comprising haemoglobin molecules with attached glucose molecules at the amino terminal valine sites, and which has been shown to be increased in the blood of diabetic patients. This paper describes an evaluation of one of the most specific methods currently available, using state-of-the-art technology. In addition to specificity, the method appears attractive in being precise, automatable (and thus operator-independent), and rapid.
糖化血红蛋白的测量是一种相对较新的临床工具，自70年代末引入以来，用于测定糖化血红蛋白的检测方法越来越多。这些检测方法在糖尿病患者尤其是妊娠糖尿病患者的长期监测中的临床实用性似乎已得到普遍认可。然而，临床医生对于这些检测方法的可靠性和解读仍存在相当大的困惑。这在很大程度上是由于当前使用的诊断方法多种多样，其中许多方法并非针对HbA1c部分具有特异性，HbA1c是血红蛋白分子在氨基末端缬氨酸位点附着葡萄糖分子的亚组分，并且已证实在糖尿病患者血液中会增加。本文描述了使用最先进技术对目前可用的最具特异性的方法之一进行的评估。除了特异性之外，该方法在精确、可自动化（因此不依赖操作人员）和快速方面似乎很有吸引力。
