Wu Lele, Chen Linxi, Li Lanfang
Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Learning Key Laboratory for Pharmacoproteomics, University of South China, Hengyang 421001, China.
Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Learning Key Laboratory for Pharmacoproteomics, University of South China, Hengyang 421001, China.
Clin Chim Acta. 2017 Mar;466:78-84. doi: 10.1016/j.cca.2016.12.023. Epub 2016 Dec 23.
Apelin is the endogenous ligand of the G protein-coupled receptor APJ. Both Apelin and APJ receptor are widely distributed in various tissues such as heart, brain, limbs, retina and liver. Recent research indicates that the Apelin/APJ system plays an important role in pathological angiogenesis which is a progress of new blood branches developing from preexisting vessels via sprouting. In this paper, we review the important role of the Apelin/APJ system in pathological angiogenesis. The Apelin/APJ system promotes angiogenesis in myocardial infarction, ischemic stroke, critical limb ischemia, tumor, retinal angiogenesis diseases, cirrhosis, obesity, diabetes and other related diseases. Furthermore, we illustrate the detailed mechanism of pathological angiogenesis induced by the Apelin/APJ system. In conclusion, the Apelin/APJ system would be a promising therapeutic target for angiogenesis-related diseases.
阿片肽是G蛋白偶联受体APJ的内源性配体。阿片肽和APJ受体广泛分布于心脏、大脑、四肢、视网膜和肝脏等各种组织中。最近的研究表明，阿片肽/APJ系统在病理性血管生成中起重要作用，病理性血管生成是指从预先存在的血管通过出芽形成新的血管分支的过程。在本文中，我们综述了阿片肽/APJ系统在病理性血管生成中的重要作用。阿片肽/APJ系统在心肌梗死、缺血性中风、严重肢体缺血、肿瘤、视网膜血管生成疾病、肝硬化、肥胖症、糖尿病及其他相关疾病中促进血管生成。此外，我们阐述了阿片肽/APJ系统诱导病理性血管生成的详细机制。总之，阿片肽/APJ系统有望成为血管生成相关疾病的治疗靶点。
