Wu Qi, Lian Ting, Fan Xiaolan, Song Chaochun, Gaur Uma, Mao Xueping, Yang Deying, Piper Matthew D W, Yang Mingyao
Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, P.R. China.
School of Biological Sciences, Monash University, Clayton, Victoria, Australia.
J Gerontol A Biol Sci Med Sci. 2017 Oct 1;72(10):1334-1341. doi: 10.1093/gerona/glw244.
The search for antiaging drugs is a key component of gerontology research. A few drugs with positive effects on life span in model organisms have been found. Here, we report that 2,5-dimethyl-celecoxib, a derivative of the anti-inflammatory drug celecoxib, can extend Drosophila life span and delay aging by a mechanism involving insulin signaling and target of rapamycin signaling. Importantly, its positive effects were apparent when the treatment window was restricted to the beginning of life or the later half. 2,5-Dimethyl-celecoxib-induced longevity was also associated with improvements in physical activity, intestinal integrity, and increased autophagy. In addition, 2,5-dimethyl-celecoxib exhibited protective effects against several kinds of stress such as starvation and heat. The generally positive effects of 2,5-dimethyl-celecoxib on both health and life span, combined with its mode of action via evolutionarily conserved signaling pathways, indicate that it has the potential to become an effective antiaging drug.
寻找抗衰老药物是老年学研究的关键组成部分。已发现一些对模式生物寿命有积极影响的药物。在此，我们报告抗炎药物塞来昔布的衍生物2,5 - 二甲基塞来昔布可通过涉及胰岛素信号传导和雷帕霉素靶标信号传导的机制延长果蝇寿命并延缓衰老。重要的是，当治疗窗口期限制在生命开始阶段或后半段时，其积极效果很明显。2,5 - 二甲基塞来昔布诱导的长寿还与身体活动能力的改善、肠道完整性以及自噬增加有关。此外，2,5 - 二甲基塞来昔布对饥饿和热等几种应激具有保护作用。2,5 - 二甲基塞来昔布对健康和寿命的总体积极影响，及其通过进化上保守的信号通路的作用方式，表明它有潜力成为一种有效的抗衰老药物。
