Burstyn Igor, De Roos Anneclaire J
Department of Environmental and Occupational Health, Dornsife School of Public Health, Drexel University, Philadelphia, PA 19104, USA.
Int J Environ Res Public Health. 2016 Dec 22;14(1):5. doi: 10.3390/ijerph14010005.
We address a methodological issue of the evaluation of the difference in effects in epidemiological studies that may arise, for example, from stratum-specific analyses or differences in analytical decisions during data analysis. We propose a new simulation-based method to quantify the plausible extent of such heterogeneity, rather than testing a hypothesis about its existence. We examine the contribution of the method to the debate surrounding risk of multiple myeloma and glyphosate use and propose that its application contributes to a more balanced weighting of evidence.
我们探讨了流行病学研究中效应差异评估的一个方法学问题，例如，这种差异可能源于分层分析或数据分析过程中分析决策的不同。我们提出了一种基于模拟的新方法，以量化这种异质性的合理程度，而不是检验关于其存在的假设。我们研究了该方法对围绕多发性骨髓瘤风险和草甘膦使用的争论的贡献，并提出其应用有助于更平衡地权衡证据。
