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PKM2 and other key regulators of Warburg effect positively correlate with CD147 (EMMPRIN) gene expression and predict survival in multiple myeloma.

作者信息

Panchabhai S, Schlam I, Sebastian S, Fonseca R

机构信息

Division of Hematology-Oncology, Mayo Clinic, Scottsdale, AZ, USA.

出版信息

Leukemia. 2017 Apr;31(4):991-994. doi: 10.1038/leu.2016.389. Epub 2016 Dec 27.

DOI:10.1038/leu.2016.389
PMID:28025580
Abstract
摘要

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PKM2 and other key regulators of Warburg effect positively correlate with CD147 (EMMPRIN) gene expression and predict survival in multiple myeloma.丙酮酸激酶M2（PKM2）和其他瓦伯格效应关键调节因子与CD147（细胞外基质金属蛋白酶诱导因子，EMMPRIN）基因表达呈正相关，并可预测多发性骨髓瘤患者的生存率。
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本文引用的文献

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Glycolysis Inhibitors for Anticancer Therapy: A Review of Recent Patents.用于抗癌治疗的糖酵解抑制剂：近期专利综述
Recent Pat Anticancer Drug Discov. 2016;11(3):297-308. doi: 10.2174/1574892811666160415160104.
2
A novel small-molecule compound targeting CD147 inhibits the motility and invasion of hepatocellular carcinoma cells.一种靶向CD147的新型小分子化合物可抑制肝癌细胞的运动性和侵袭性。
Oncotarget. 2016 Feb 23;7(8):9429-47. doi: 10.18632/oncotarget.6990.
3
Pyruvate kinase isoform M2 (PKM2) participates in multiple myeloma cell proliferation, adhesion and chemoresistance.
CD147 在血液系统恶性肿瘤中的代谢功能及治疗潜力：综述。
Int J Mol Sci. 2024 Aug 23;25(17):9178. doi: 10.3390/ijms25179178.
4
Targeting natural killer cells: from basic biology to clinical application in hematologic malignancies.靶向自然杀伤细胞：从基础生物学到血液系统恶性肿瘤的临床应用
Exp Hematol Oncol. 2024 Feb 23;13(1):21. doi: 10.1186/s40164-024-00481-y.
5
Shutting off the fuel supply to target metabolic vulnerabilities in multiple myeloma.切断燃料供应以针对多发性骨髓瘤的代谢脆弱点。
Front Oncol. 2023 Jun 8;13:1141851. doi: 10.3389/fonc.2023.1141851. eCollection 2023.
6
Metabolic changes underlying drug resistance in the multiple myeloma tumor microenvironment.多发性骨髓瘤肿瘤微环境中耐药性背后的代谢变化。
Front Oncol. 2023 Apr 6;13:1155621. doi: 10.3389/fonc.2023.1155621. eCollection 2023.
7
Extracellular Vesicles Isolated from Plasma of Multiple Myeloma Patients Treated with Daratumumab Express CD38, PD-L1, and the Complement Inhibitory Proteins CD55 and CD59.从接受达雷妥尤单抗治疗的多发性骨髓瘤患者的血浆中分离出的细胞外囊泡表达 CD38、PD-L1 以及补体抑制蛋白 CD55 和 CD59。
Cells. 2022 Oct 25;11(21):3365. doi: 10.3390/cells11213365.
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Multi-omics tumor profiling technologies to develop precision medicine in multiple myeloma.用于多发性骨髓瘤精准医学发展的多组学肿瘤分析技术。
Explor Target Antitumor Ther. 2021;2(1):65-106. doi: 10.37349/etat.2021.00034. Epub 2021 Feb 28.
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Front Oncol. 2022 May 26;12:866289. doi: 10.3389/fonc.2022.866289. eCollection 2022.
丙酮酸激酶同工酶M2（PKM2）参与多发性骨髓瘤细胞的增殖、黏附和化疗耐药。
Leuk Res. 2015 Dec;39(12):1428-36. doi: 10.1016/j.leukres.2015.09.019. Epub 2015 Sep 28.
4
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Leukemia. 2016 Apr;30(4):951-4. doi: 10.1038/leu.2015.191. Epub 2015 Jul 23.
5
The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells.亲环素A-CD147复合物促进多发性骨髓瘤细胞的增殖和归巢。
Nat Med. 2015 Jun;21(6):572-80. doi: 10.1038/nm.3867. Epub 2015 May 25.
6
Metabolic signature identifies novel targets for drug resistance in multiple myeloma.代谢特征确定了多发性骨髓瘤耐药性的新靶点。
Cancer Res. 2015 May 15;75(10):2071-82. doi: 10.1158/0008-5472.CAN-14-3400. Epub 2015 Mar 13.
7
Activators of PKM2 in cancer metabolism.癌症代谢中PKM2的激活剂。
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Nature. 2014 Sep 25;513(7519):559-63. doi: 10.1038/nature13490. Epub 2014 Jul 13.
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Monocarboxylate transporters as targets and mediators in cancer therapy response.单羧酸转运体作为癌症治疗反应中的靶点和介质
Histol Histopathol. 2014 Dec;29(12):1511-24. doi: 10.14670/HH-29.1511. Epub 2014 Jun 12.
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CD147 regulates the expression of MCT1 and lactate export in multiple myeloma cells.CD147 调节多发性骨髓瘤细胞中 MCT1 的表达和乳酸的外排。
Cell Cycle. 2013 Oct 1;12(19):3175-83. doi: 10.4161/cc.26193. Epub 2013 Sep 3.