• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

头颈部非肿瘤性疾病的医学治疗证据及证据空白

Evidence and evidence gaps of medical treatment of non-tumorous diseases of the head and neck.

作者信息

Bas Murat

机构信息

Department of Otolaryngology, Technische Universität München, Germany.

出版信息

GMS Curr Top Otorhinolaryngol Head Neck Surg. 2016 Dec 15;15:Doc02. doi: 10.3205/cto000129. eCollection 2016.

DOI:10.3205/cto000129
PMID:28025602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5169075/
Abstract

Unfortunately, the treatment of numerous otolaryngological diseases often lacks of evidence base because appropriate studies are missing. Whereas sufficient high-quality trials exist for the specific immunotherapy of allergic rhinitis and in a limited measure also for the angiotensin-converting enzyme inhibitor induced angioedema, the evidence for Menière's disease or for pharmacotherapy of postoperative laryngeal edema is rather poor. This contribution will discuss the trial situation and evidence of the respective diseases.

摘要

不幸的是，由于缺乏适当的研究，众多耳鼻喉科疾病的治疗往往缺乏循证依据。虽然针对过敏性鼻炎的特异性免疫疗法有足够的高质量试验，在一定程度上针对血管紧张素转换酶抑制剂诱发的血管性水肿也有相关试验，但关于梅尼埃病或术后喉水肿药物治疗的证据相当匮乏。本文将讨论这些疾病各自的试验情况和证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/af82dfa0f68d/CTO-15-02-g-007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/2f1abebed6d9/CTO-15-02-t-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/1af1721d2302/CTO-15-02-t-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/35287535dd0c/CTO-15-02-t-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/21c53cf4c413/CTO-15-02-t-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/8e481184da3c/CTO-15-02-t-005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/50a89c93da5e/CTO-15-02-t-006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/48af81dc4410/CTO-15-02-t-007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/de149fbcec97/CTO-15-02-g-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/97ad1335f18f/CTO-15-02-g-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/e6a2b21130e5/CTO-15-02-g-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/4a72e7bf2cd5/CTO-15-02-g-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/ec666cd992a0/CTO-15-02-g-005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/bbf9a68c7407/CTO-15-02-g-006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/af82dfa0f68d/CTO-15-02-g-007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/2f1abebed6d9/CTO-15-02-t-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/1af1721d2302/CTO-15-02-t-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/35287535dd0c/CTO-15-02-t-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/21c53cf4c413/CTO-15-02-t-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/8e481184da3c/CTO-15-02-t-005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/50a89c93da5e/CTO-15-02-t-006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/48af81dc4410/CTO-15-02-t-007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/de149fbcec97/CTO-15-02-g-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/97ad1335f18f/CTO-15-02-g-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/e6a2b21130e5/CTO-15-02-g-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/4a72e7bf2cd5/CTO-15-02-g-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/ec666cd992a0/CTO-15-02-g-005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/bbf9a68c7407/CTO-15-02-g-006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1444/5169075/af82dfa0f68d/CTO-15-02-g-007.jpg

相似文献

1
Evidence and evidence gaps of medical treatment of non-tumorous diseases of the head and neck.头颈部非肿瘤性疾病的医学治疗证据及证据空白
GMS Curr Top Otorhinolaryngol Head Neck Surg. 2016 Dec 15;15:Doc02. doi: 10.3205/cto000129. eCollection 2016.
2
[Strong and Deficient Evidence in Drug-Treated, Non-Tumorous Diseases in ENT].[耳鼻喉科药物治疗非肿瘤性疾病的强证据和弱证据]
Laryngorhinootologie. 2016 Apr;95 Suppl 1:S217-32. doi: 10.1055/s-0041-108940. Epub 2016 Apr 29.
3
[Angioneurotic edema of the head and neck in association with ACE inhibitors].[血管紧张素转换酶抑制剂相关性头颈部血管性水肿]
HNO. 2007 Sep;55(9):709-15. doi: 10.1007/s00106-006-1511-7.
4
[ACE-inhibitor induced angioedema].[血管紧张素转换酶抑制剂诱发的血管性水肿]
Laryngorhinootologie. 2007 Nov;86(11):804-8, quiz 809-13. doi: 10.1055/s-2007-966932.
5
Angiotensin-converting enzyme inhibitor induced angioedema of the head and neck.血管紧张素转换酶抑制剂诱发的头颈部血管性水肿。
Trans Pa Acad Ophthalmol Otolaryngol. 1990;42:998-1001.
6
Angiotensin Converting Enzyme Inhibitor-related Angioedema: A Case of an Unexpected Death.血管紧张素转换酶抑制剂相关的血管性水肿：一例意外死亡病例
Iran J Allergy Asthma Immunol. 2015 Dec;14(6):642-5.
7
Angioedema from angiotensin-converting enzyme (ACE) inhibitor treated with complement 1 (C1) inhibitor concentrate.用补体1（C1）抑制剂浓缩物治疗血管紧张素转换酶（ACE）抑制剂引起的血管性水肿。
Acta Anaesthesiol Scand. 2006 Jan;50(1):120-2. doi: 10.1111/j.1399-6576.2005.00819.x.
8
[Extensive head-neck edema. Angioneurotic edema caused by angiotensin converting enzyme (ACE) inhibitor].[广泛头颈部水肿。由血管紧张素转换酶（ACE）抑制剂引起的血管性水肿]
HNO. 1997 Dec;45(12):1016-7.
9
Drug-Induced Inhibition of Angiotensin Converting Enzyme and Dipeptidyl Peptidase 4 Results in Nearly Therapy Resistant Bradykinin Induced Angioedema: A Case Report.药物诱导的血管紧张素转换酶和二肽基肽酶4抑制导致几乎治疗抵抗性的缓激肽诱导的血管性水肿：一例报告
Am J Case Rep. 2017 May 25;18:576-579. doi: 10.12659/ajcr.901960.
10
The role of icatibant-the B2 bradykinin receptor antagonist-in life-threatening laryngeal angioedema in the ED.依卡替班（一种B2缓激肽受体拮抗剂）在急诊科危及生命的喉血管性水肿中的作用。
Am J Emerg Med. 2015 Mar;33(3):479.e1-3. doi: 10.1016/j.ajem.2014.08.055. Epub 2014 Aug 27.

引用本文的文献

1
New Insight into Laryngo-Tracheal Surgery: High-Flow Oxygen Therapy to Prevent Early Complications after Surgery.喉气管手术的新见解：高流量氧疗预防术后早期并发症
J Pers Med. 2024 Apr 25;14(5):456. doi: 10.3390/jpm14050456.

本文引用的文献

1
Guideline on allergen-specific immunotherapy in IgE-mediated allergic diseases: S2k Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Society for Pediatric Allergy and Environmental Medicine (GPA), the Medical Association of German Allergologists (AeDA), the Austrian Society for Allergy and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Dermatology (DDG), the German Society of Oto- Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), the German Society of Pediatrics and Adolescent Medicine (DGKJ), the Society for Pediatric Pneumology (GPP), the German Respiratory Society (DGP), the German Association of ENT Surgeons (BV-HNO), the Professional Federation of Paediatricians and Youth Doctors (BVKJ), the Federal Association of Pulmonologists (BDP) and the German Dermatologists Association (BVDD).IgE介导的过敏性疾病中变应原特异性免疫治疗指南：德国变态反应学与临床免疫学会（DGAKI）、儿科变态反应与环境医学学会（GPA）、德国变态反应科医生医学协会（AeDA）、奥地利变态反应与免疫学会（ÖGAI）、瑞士变态反应与免疫学会（SGAI）、德国皮肤病学会（DDG）、德国耳鼻咽喉头颈外科学会（DGHNO-KHC）、德国儿科学与青少年医学学会（DGKJ）、儿科肺病学会（GPP）、德国呼吸学会（DGP）、德国耳鼻喉外科医生协会（BV-HNO）、儿科医生与青年医生专业联合会（BVKJ）、肺科医生联邦协会（BDP）以及德国皮肤科医生协会（BVDD）的S2k指南
Allergo J Int. 2014;23(8):282-319. doi: 10.1007/s40629-014-0032-2.
2
Angiotensin-converting enzyme inhibitors-induced angioedema treated by C1 esterase inhibitor concentrate (Berinert®): about one case and review of the therapeutic arsenal.用C1酯酶抑制剂浓缩物（贝林妥欧®）治疗血管紧张素转换酶抑制剂引起的血管性水肿：1例病例及治疗方法综述
Clin Case Rep. 2015 Feb;3(2):126-30. doi: 10.1002/ccr3.171. Epub 2014 Dec 5.
3
A randomized trial of icatibant in ACE-inhibitor-induced angioedema.依替巴肽治疗血管性水肿的随机试验。
N Engl J Med. 2015 Jan 29;372(5):418-25. doi: 10.1056/NEJMoa1312524.
4
Effect of C1-Esterase-inhibitor in angiotensin-converting enzyme inhibitor-induced angioedema.C1酯酶抑制剂在血管紧张素转换酶抑制剂所致血管性水肿中的作用。
Laryngoscope. 2015 Jun;125(6):E198-202. doi: 10.1002/lary.25113. Epub 2015 Jan 13.
5
An evidence-based analysis of house dust mite allergen immunotherapy: a call for more rigorous clinical studies.基于证据的室内尘螨变应原免疫治疗分析：呼吁开展更严格的临床研究。
J Allergy Clin Immunol. 2013 Dec;132(6):1322-36. doi: 10.1016/j.jaci.2013.09.004. Epub 2013 Oct 18.
6
ACE-inhibitor induced angio-oedema treated with complement C1-inhibitor concentrate.用补体C1抑制物浓缩物治疗血管紧张素转换酶抑制剂诱发的血管性水肿。
BMJ Case Rep. 2013 Oct 4;2013:bcr2013200652. doi: 10.1136/bcr-2013-200652.
7
Subcutaneous and sublingual immunotherapy for seasonal allergic rhinitis: a systematic review and indirect comparison.皮下和舌下免疫疗法治疗季节性变应性鼻炎：系统评价和间接比较。
J Allergy Clin Immunol. 2013 May;131(5):1361-6. doi: 10.1016/j.jaci.2013.02.013. Epub 2013 Apr 1.
8
Cost effectiveness analysis of immunotherapy in patients with grass pollen allergic rhinoconjunctivitis in Germany.德国草花粉过敏鼻炎患者免疫治疗的成本效益分析。
J Med Econ. 2012;15(5):906-17. doi: 10.3111/13696998.2012.688904. Epub 2012 May 24.
9
[Prevalence and socio-economic relevance of allergies in Germany].[德国过敏症的患病率及社会经济相关性]
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2012 Mar;55(3):303-7. doi: 10.1007/s00103-011-1427-6.
10
Intratympanic treatment of intractable unilateral Meniere disease: gentamicin or dexamethasone? A randomized controlled trial.鼓室内治疗难治性单侧梅尼埃病：庆大霉素或地塞米松？一项随机对照试验。
Otolaryngol Head Neck Surg. 2012 Mar;146(3):430-7. doi: 10.1177/0194599811429432. Epub 2011 Nov 18.