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资源有限环境下的甲状腺手术

Thyroid Surgery in a Resource-Limited Setting.

作者信息

Jafari Aria, Campbell David, Campbell Bruce H, Ngoitsi Henry Nono, Sisenda Titus M, Denge Makaya, James Benjamin C, Cordes Susan R

机构信息

1 Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego, San Diego, California, USA.

2 Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

出版信息

Otolaryngol Head Neck Surg. 2017 Mar;156(3):464-471. doi: 10.1177/0194599816684097. Epub 2016 Dec 27.

Abstract

Objective The present study reviews a series of patients who underwent thyroid surgery in Eldoret, Kenya, to demonstrate the feasibility of conducting long-term (>1 year) outcomes research in a resource-limited setting, impact on the quality of life of the recipient population, and inform future humanitarian collaborations. Study Design Case series with chart review. Setting Tertiary public referral hospital in Eldoret, Kenya. Subjects and Methods Twenty-one patients were enrolled during the study period. A retrospective chart review was performed for all adult patients who underwent thyroid surgery during humanitarian trips (2010-2015). Patients were contacted by mobile telephone. Medical history and physical examination, including laryngoscopy, were performed, and the SF-36 was administered (a quality-of-life questionnaire). Laboratory measurements of thyroid function and neck ultrasound were obtained. Results The mean follow-up was 33.6 ± 20.2 months after surgery: 37.5% of subtotal thyroidectomy patients and 15.4% of lobectomy patients were hypothyroid postoperatively according to serologic studies. There were no cases of goiter recurrence or malignancy. All patients reported postoperative symptomatic improvement and collectively showed positive pre- and postoperative score differences on the SF-36. Conclusion Although limited by a small sample size and the retrospective nature, our study demonstrates the feasibility of long-term surgical and quality-of-life outcomes research in a resource-limited setting. The low complication rates suggest minimal adverse effects of performing surgery in this context. Despite a considerable rate of postoperative hypothyroidism, it is in accordance with prior studies and emphasizes the need for individualized, longitudinal, and multidisciplinary care. Quality-of-life score improvements suggest benefit to the recipient population.

摘要

目的 本研究回顾了在肯尼亚埃尔多雷特接受甲状腺手术的一系列患者,以证明在资源有限的环境中开展长期(>1年)结局研究的可行性、对受助人群生活质量的影响,并为未来的人道主义合作提供参考。研究设计 病例系列研究并进行图表回顾。研究地点 肯尼亚埃尔多雷特的三级公立转诊医院。研究对象与方法 在研究期间纳入了21例患者。对在人道主义医疗行动期间(2010 - 2015年)接受甲状腺手术的所有成年患者进行了回顾性图表审查。通过移动电话与患者取得联系。进行了病史采集和体格检查,包括喉镜检查,并发放了SF - 36量表(一种生活质量问卷)。还进行了甲状腺功能的实验室检测和颈部超声检查。结果 术后平均随访时间为33.6 ± 20.2个月:根据血清学研究,甲状腺次全切除术患者中有37.5%、甲状腺叶切除术患者中有15.4%术后出现甲状腺功能减退。没有甲状腺肿复发或恶性肿瘤的病例。所有患者均报告术后症状有所改善,并且在SF - 36量表上术前和术后的得分总体呈正向差异。结论 尽管本研究受样本量小和回顾性研究性质的限制,但仍证明了在资源有限的环境中开展长期手术和生活质量结局研究的可行性。低并发症发生率表明在此环境下进行手术的不良影响最小。尽管术后甲状腺功能减退的发生率较高,但这与先前的研究一致,并强调了个体化、纵向和多学科护理的必要性。生活质量得分的提高表明对受助人群有益。

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