Richter Bertram, Harinath Lakshmi, Pu Cunfeng, Stabingas Kristen
Clin Neuropathol. 2017 Mar/Apr;36 (2017)(2):60-65. doi: 10.5414/NP300980.
Metastatic spread of a systemic neoplasm to a central nervous system malignancy is a rare but well-documented phenomenon. Over 100 case reports of tumor-to-tumor spread involving the central nervous system have been described since the first report in 1930. Overwhelmingly, intracranial meningioma represents the most common recipient tumor, while breast and lung are the first and second most common donor malignancies, respectively. The propensity for meningiomas to harbor metastatic lesions has been attributed to cell-to-cell adhesion molecules, favorable metabolic environment as well as hormonal and mechanical factors. We distinguish the concepts of true "tumor-to-tumor metastasis" and "tumor collision" and discuss potential non-invasive diagnostic modalities that may aid in preoperatively identifying intracranial lesions harboring distal metastasis. We present the first incidence, to our knowledge, of metastatic esophageal carcinoma spread to intracranial meningioma. .
系统性肿瘤转移至中枢神经系统恶性肿瘤是一种罕见但有充分文献记载的现象。自1930年首次报告以来，已有100多例涉及中枢神经系统的肿瘤-to-肿瘤转移的病例报告。绝大多数情况下，颅内脑膜瘤是最常见的受主肿瘤，而乳腺癌和肺癌分别是最常见的供体恶性肿瘤中的第一和第二种。脑膜瘤易发生转移病变的倾向归因于细胞间粘附分子、有利的代谢环境以及激素和机械因素。我们区分了真正的“肿瘤-to-肿瘤转移”和“肿瘤碰撞”的概念，并讨论了可能有助于术前识别存在远处转移的颅内病变的潜在非侵入性诊断方法。据我们所知，我们首次报道了转移性食管癌扩散至颅内脑膜瘤的病例。
