铑催化的β-支链酰胺的不对称合成。
Rhodium-Catalyzed Asymmetric Synthesis of β-Branched Amides.
机构信息
Department of Chemistry, University of Illinois, Urbana-Champaign, 600 S. Mathews, Urbana, IL, 61821, USA.
出版信息
Angew Chem Int Ed Engl. 2017 Jan 24;56(5):1371-1375. doi: 10.1002/anie.201610500. Epub 2016 Dec 27.
PMID:28026091
Abstract
A general asymmetric route for the one-step synthesis of chiral β-branched amides is reported through the highly enantioselective isomerization of allylamines, followed by enamine exchange, and subsequent oxidation. The enamine exchange allows for a rapid and modular synthesis of various amides, including challenging β-diaryl and β-cyclic.
摘要
本文报道了一种通过高对映选择性烯丙胺异构化、随后进行烯胺交换和后续氧化反应，一步合成手性β-支链酰胺的通用不对称方法。烯胺交换允许快速和模块化合成各种酰胺，包括具有挑战性的β-二芳基和β-环状酰胺。
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