Nihayah Saeed, Shammas Amer, Vali Reza, Parra Dimitri, Alexander Sarah, Amaral Joao, Connolly Bairbre
1 Department of Radiology, Prince Sultan Military Medical City, PO Box 7897, Riyadh 11159, Kingdom of Saudi Arabia.
2 Division of Image Guided Therapy, Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada.
AJR Am J Roentgenol. 2017 Mar;208(3):656-662. doi: 10.2214/AJR.15.15914. Epub 2016 Dec 27.
The purpose of this study was to evaluate an early experience with correlation of PET/CT findings and image-guided biopsy results in pediatric patients.
In a single-center retrospective case series, the inclusion criterion was performance of image-guided biopsy within 6 weeks of PET/CT, either before or after the biopsy.
Forty-five patients (23 boys, 22 girls; age range, 4-17 years; median, 10.5 years; weight range, 14.6-86.2 kg; median, 48 kg) underwent 47 PET/CT examinations and biopsies. Nineteen patients (20 biopsies) had known malignancy, and 26 patients had suspected malignancy. The results were malignant in 24 cases, benign in 16, and inadequate or normal in 7 cases. Thirty-nine of 47 PET/CT examinations had positive results, and eight had negative results. Final analysis of 37 of the 47 cases (confounders excluded) showed concordant results between biopsy and PET in 36 cases and discordant results in one case.
PET/CT can be used for disease staging and follow-up. In the future PET/CT can play a valuable role in directing image-guided biopsies of children.
本研究的目的是评估小儿患者中PET/CT检查结果与影像引导下活检结果相关性的早期经验。
在一项单中心回顾性病例系列研究中，纳入标准为在PET/CT检查的6周内（活检前后均可）进行影像引导下活检。
45例患者（23例男孩，22例女孩；年龄范围4 - 17岁，中位数10.5岁；体重范围14.6 - 86.2 kg，中位数48 kg）接受了47次PET/CT检查及活检。19例患者（20次活检）已知患有恶性肿瘤，26例患者怀疑患有恶性肿瘤。结果显示24例为恶性，16例为良性，7例结果不充分或正常。47次PET/CT检查中39次结果为阳性，8次为阴性。对47例中的37例（排除混杂因素）进行最终分析显示，活检与PET结果一致的有36例，不一致的有1例。
PET/CT可用于疾病分期及随访。未来，PET/CT在指导儿童影像引导下活检方面可发挥重要作用。
