红曲霉素，一种来自红曲米的特殊γ-内酰胺。
Monascustin, an Unusual γ-Lactam from Red Yeast Rice.
作者信息
Wei Wendi, Lin Sheng, Chen Minghua, Liu Tianxi, Wang Ali, Li Jinjie, Guo Qinglan, Shang Xiaoya
机构信息
Beiijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University , Beijing 100191, People's Republic of China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
出版信息
J Nat Prod. 2017 Jan 27;80(1):201-204. doi: 10.1021/acs.jnatprod.6b00493. Epub 2016 Dec 27.
Monascustin (1), an unusual γ-lactam, was isolated from an ethanol extract of the Monascus purpureus fermented rice. Its structure including the absolute configuration was determined by spectroscopic data analysis and confirmed by X-ray crystallography. A plausible biosynthetic pathway is discussed on the basis of amino acid derivatization. Compound 1 showed inhibitory activity against histone deacetylase 1.
红曲菌素（1）是一种不寻常的γ-内酰胺，从紫红曲霉发酵大米的乙醇提取物中分离得到。通过光谱数据分析确定了其结构，包括绝对构型，并通过X射线晶体学得到证实。基于氨基酸衍生化讨论了一种可能的生物合成途径。化合物1对组蛋白去乙酰化酶1显示出抑制活性。
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