Division of Chemistry and Chemical Engineering, California Institute of Technology , Pasadena, California 91125, United States.
J Am Chem Soc. 2017 Feb 1;139(4):1668-1674. doi: 10.1021/jacs.6b12114. Epub 2017 Jan 20.
Disclosed is a mild, scalable, and chemoselective catalytic cross-dehydrogenative C-H bond functionalization protocol for the construction of C(sp)-Si bonds in a single step. The scope of the alkyne and hydrosilane partners is substantial, providing an entry point into various organosilane building blocks and additionally enabling the discovery of a number of novel synthetic strategies. Remarkably, the optimal catalysts are NaOH and KOH.
本发明公开了一种温和、可扩展且化学选择性的催化交叉脱氢 C-H 键官能化方法，可一步构建 C(sp)-Si 键。炔烃和硅烷的适用范围很广，为各种有机硅砌块的合成提供了切入点，并进一步发现了许多新的合成策略。值得注意的是，最佳催化剂是 NaOH 和 KOH。
