Esatbeyoglu Tuba, Obermair Betina, Dorn Tabea, Siems Karsten, Rimbach Gerald, Birringer Marc
1 Institute of Human Nutrition and Food Science, Christian-Albrechts-University of Kiel , Kiel, Germany .
2 Department of Nutritional, Food, and Consumer Sciences, University of Applied Sciences Fulda , Fulda, Germany .
J Med Food. 2017 Jan;20(1):71-78. doi: 10.1089/jmf.2016.0105. Epub 2016 Dec 27.
Taraxacum officinale, the common dandelion, is a plant of the Asteraceae family, which is used as a food and medical herb. Various secondary plant metabolites such as sesquiterpene lactones, triterpenoids, flavonoids, phenolic acids, coumarins, and steroids have been described to be present in T. officinale. Dandelion may exhibit various health benefits, including antioxidant, anti-inflammatory, and anticarcinogenic properties. We analyzed the leaves and roots of the common dandelion (T. officinale) using high-performance liquid chromatography/mass spectrometry to determine its sesquiterpene lactone composition. The main compound of the leaf extract taraxinic acid β-d-glucopyranosyl ester (1), a sesquiterpene lactone, was isolated and the structure elucidation was conducted by nuclear magnetic resonance spectrometry. The leaf extract and its main compound 1 activated the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) in human hepatocytes more significantly than the root extract. Furthermore, the leaf extract induced the Nrf2 target gene heme oxygenase 1. Overall, present data suggest that compound 1 may be one of the active principles of T. officinale.
药用蒲公英，即普通蒲公英，是菊科植物，可作为食物和药草。已有报道称药用蒲公英中存在各种次生植物代谢产物，如倍半萜内酯、三萜类化合物、黄酮类化合物、酚酸、香豆素和甾体类化合物。蒲公英可能具有多种健康益处，包括抗氧化、抗炎和抗癌特性。我们使用高效液相色谱/质谱法分析了普通蒲公英（药用蒲公英）的叶子和根部，以确定其倍半萜内酯成分。叶提取物的主要化合物蒲公英酸β - d - 吡喃葡萄糖酯（1），一种倍半萜内酯，被分离出来，并通过核磁共振光谱法进行结构解析。叶提取物及其主要化合物1在人肝细胞中比根提取物更显著地激活转录因子核因子红细胞2相关因子2（Nrf2）。此外，叶提取物诱导了Nrf2靶基因血红素加氧酶1。总体而言，现有数据表明化合物1可能是药用蒲公英的活性成分之一。
