Herrera Vielma Francisca, Quiñones San Martin Matías, Muñoz-Carrasco Nicolás, Berrocal-Navarrete Fernanda, González Daniel R, Zúñiga-Hernández Jessica
Pharmacology Laboratory, Biomedical Sciences Department, Faculty of Health Sciences, University of Talca, Talca 3465548, Chile.
Doctorate Program in Science, Mention in Research and Development of Bioactive Products, Institute of Chemistry of Natural Resources, University of Talca, Talca 3465548, Chile.
Pharmaceuticals (Basel). 2025 Jul 1;18(7):990. doi: 10.3390/ph18070990.
(), commonly known as dandelion, is a plant with recognized therapeutic properties in both traditional and modern medicine. Historically, it has been used to treat various conditions, particularly liver disorders, owing to its antioxidant and anti-inflammatory activities. This narrative review focuses on its biological activity, with an emphasis on hepatoprotective effects. We performed a compilation and analysis of published studies on the effects of in animal models and its potential application in liver diseases. Preclinical studies have reported that extracts of this plant protect against liver damage induced by toxic agents such as alcohol, carbon tetrachloride, and paracetamol. Among the most relevant and predominant bioactive compounds of is taraxasterol, which modulates inflammatory and oxidative stress pathways, helping to prevent liver damage. While preclinical studies are promising, further clinical trials are essential to confirm the safety and efficacy of in the treatment of liver diseases. Determining the optimal dosing, evaluating its potential as an adjuvant in pharmacological treatments, as well as evaluating possible interactions with conventional drugs, is necessary for the potential use of as an adjuvant agent in the treatment of liver diseases.
（），通常被称为蒲公英，是一种在传统医学和现代医学中都具有公认治疗特性的植物。从历史上看，由于其抗氧化和抗炎活性，它一直被用于治疗各种病症，特别是肝脏疾病。这篇叙述性综述聚焦于其生物活性，重点是肝脏保护作用。我们对已发表的关于（）在动物模型中的作用及其在肝脏疾病中的潜在应用的研究进行了汇编和分析。临床前研究报告称，这种植物的提取物可保护肝脏免受酒精、四氯化碳和对乙酰氨基酚等有毒物质引起的损伤。（）最相关且主要的生物活性化合物是蒲公英甾醇，它可调节炎症和氧化应激途径，有助于预防肝脏损伤。虽然临床前研究很有前景，但进一步的临床试验对于确认（）在治疗肝脏疾病中的安全性和有效性至关重要。确定最佳剂量、评估其作为药理学治疗辅助剂的潜力以及评估与传统药物可能的相互作用，对于（）作为肝脏疾病治疗辅助剂的潜在用途而言是必要的。
