Kessler H H, Dohr G, Desoye G, Winter R
Universitäts-Frauenklinik Graz.
Arch Gynecol Obstet. 1989;245(1-4):161-2. doi: 10.1007/BF02417223.
The expression of HLA antigens on polyploid human preimplantation embryos, obtained in an in vitro fertilization program, was investigated by indirect immunofluorescence test using a panel of well-defined monoclonal antibodies. Neither HLA class I antigens and beta 2-microglobulin, nor HLA class II molecules could be detected on blastomeres and the zona pellucida. It is supposed that the absence of HLA antigens on human preimplantation embryos may be one of the mechanisms important for the acceptance of the embryo by the immunocompetent mother.
通过使用一组高度特异性的单克隆抗体进行间接免疫荧光试验，研究了在体外受精程序中获得的多倍体人类植入前胚胎上HLA抗原的表达。在卵裂球和透明带上均未检测到HLA I类抗原和β2-微球蛋白，也未检测到HLA II类分子。据推测，人类植入前胚胎上缺乏HLA抗原可能是免疫活性母亲接受胚胎的重要机制之一。
