Chu Chen, Zhou Nan, Zhang Huayong, Dou Xin, Li Ming, Liu Song, Zhu Yun, Chen Weibo, Chan Queenie, He Jian, Sun Lingyun, Zhou Zhengyang
Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.
Department of Rheumatology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.
Eur J Radiol. 2017 Jan;86:241-247. doi: 10.1016/j.ejrad.2016.11.021. Epub 2016 Nov 27.
To explore the correlation between intravoxel incoherent motion (IVIM) magnetic resonance (MR) parameters and MR nodular grade of parotid glands in patients with Sjögren's syndrome (SS).
A total of 31 consecutive patients with SS and 28 gender- and age-matched healthy volunteers underwent bilateral parotid 3.0T MR examination including the IVIM sequence (9 b values, 0-800s/mm). The apparent diffusion coefficient (ADC), diffusion coefficient D, pseudo-diffusion coefficient D, and perfusion fraction f of bilateral parotid glands were obtained, and the nodular grade of each parotid gland was evaluated according to the MR morphological appearance.
Sixty-two parotid glands in 31 patients with SS consisted of 32, 14, 8, and 8 parotid glands at MR nodular grades 0, 1, 2, and 3, respectively. In parotid glands of grade 0, 1, 2, 3 and healthy volunteers, the ADC values were (1.13±0.25, 1.11±0.17, 1.05±0.24, 0.89±0.04 and 1.00±0.21)×10mm/s, D values were (0.92±0.13, 0.90±0.19, 0.90±0.03, 0.67±0.03, 0.81±0.03)×10mm/s, f values were 0.20±0.04, 0.18±0.02, 0.15±0.01, 0.11±0.01, 0.15±0.06, and Dvalues were (53.89±28.26, 41.78±16.35, 51.24±18.69, 31.83±18.03, 36.83±16.14)×10mm/s respectively. The ADC, D, f, and D values of parotid glands in patients with SS at grade 0 were significantly higher than those in healthy volunteers (all P<0.05). Significant differences were observed in the D and f values of parotid glands in patients with SS among different grades (P=0.003,<0.001, respectively). The IVIM parameters (D, f) of parotid glands at early (grades 0-1) and advanced (grades 2-3) stages in patients with SS were significantly higher and lower, respectively, than those in healthy volunteers (all P<0.05). The D and f values inversely correlated with MR nodular grades significantly (r=- 0.297, P=0.019; r=- 0.653, P<0.001, respectively) CONCLUSION: The parotid glands with different MR nodular grades in patients with SS showed different IVIM parameters, reflecting different pathophysiological characteristics of parotid glands at different stages.
探讨干燥综合征（SS）患者腮腺体素内不相干运动（IVIM）磁共振（MR）参数与MR结节分级之间的相关性。
连续纳入31例SS患者及28例性别和年龄匹配的健康志愿者，对双侧腮腺进行3.0T MR检查，包括IVIM序列（9个b值，0 - 800s/mm²）。获取双侧腮腺的表观扩散系数（ADC）、扩散系数D、伪扩散系数D*及灌注分数f，并根据MR形态表现评估各腮腺的结节分级。
31例SS患者的62个腮腺中，MR结节分级为0、1、2、3级的腮腺分别有32、14、8和8个。0、1、2、3级腮腺及健康志愿者腮腺的ADC值分别为(1.13±0.25、1.11±0.17、1.05±0.24、0.89±0.04和1.00±0.21)×10⁻³mm²/s，D值分别为(0.92±0.13、0.90±0.19、0.90±0.03、0.67±0.03、0.81±0.03)×10⁻³mm²/s，f值分别为0.20±0.04、0.18±0.02、0.15±0.01、0.11±0.01、0.15±0.06，D值分别为(53.89±28.26、41.78±16.35、51.24±18.69、31.83±18.03、36.83±16.14)×10⁻³mm²/s。SS患者0级腮腺的ADC、D、f及D值均显著高于健康志愿者（均P<0.05）。不同分级的SS患者腮腺的D及f值存在显著差异（分别为P = 0.003，P<0.001）。SS患者早期（0 - 1级）和晚期（2 - 3级）腮腺的IVIM参数（D、f）分别显著高于和低于健康志愿者（均P<0.05）。D及f值与MR结节分级呈显著负相关（r = - 0.297，P = 0.019；r = - 0.653，P<0.001）。
SS患者不同MR结节分级的腮腺表现出不同的IVIM参数，反映了腮腺在不同阶段的不同病理生理特征。
