Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing, P.R. China.
Department of Rheumatology, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing, P.R. China.
J Magn Reson Imaging. 2017 Nov;46(5):1409-1417. doi: 10.1002/jmri.25697. Epub 2017 Mar 21.
To explore the role of diffusion kurtosis imaging (DKI) of parotid glands in diagnosing Sjögren's syndrome (SS).
A total of 40 patients with SS and 40 healthy volunteers underwent 3.0T magnetic resonance imaging (MRI) including DKI, which generated the apparent diffusion coefficient (ADC), corrected diffusion (D), and diffusional kurtosis (K) values. The MR nodular grade was determined on the basis of MR morphological findings.
The parotid ADC, D, and K values in patients with SS were significantly higher than those of healthy volunteers (P = 0.011, < 0.001, 0.022, respectively). The parotid ADC and D values in patients with SS of MR nodular grade 0 were significantly higher than those of healthy volunteers (all P < 0.001). The parotid D value showed an accuracy of 75.0% and 87.9% in diagnosing patients with SS and MR nodular grade 0, respectively. The parotid ADC and D values correlated negatively, while the K values correlated positively with the MR nodular grade significantly in patients with SS (r = -0.741, -0.605, 0.424, all P < 0.001). All parotid DKI parameters differed significantly among patients with SS at different MR nodular grades (all P < 0.001).
Parotid DKI parameters hold great potential in diagnosing SS, especially in early-stage SS without MR morphological changes.
2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2017;46:1409-1417.
探讨腮腺扩散峰度成像（DKI）在诊断干燥综合征（SS）中的作用。
共 40 例 SS 患者和 40 例健康志愿者行 3.0T 磁共振成像（MRI）检查，包括 DKI，生成表观扩散系数（ADC）、校正扩散（D）和扩散峰度（K）值。根据 MRI 形态学发现确定 MR 结节分级。
SS 患者的腮腺 ADC、D 和 K 值明显高于健康志愿者（P=0.011，<0.001，0.022）。MR 结节分级为 0 级的 SS 患者腮腺 ADC 和 D 值明显高于健康志愿者（均 P<0.001）。腮腺 D 值诊断 SS 患者和 MR 结节分级为 0 级患者的准确率分别为 75.0%和 87.9%。SS 患者腮腺 ADC 和 D 值与 MR 结节分级呈负相关，K 值与 MR 结节分级呈正相关（r=-0.741，-0.605，0.424，均 P<0.001）。不同 MR 结节分级的 SS 患者腮腺 DKI 各参数差异均有统计学意义（均 P<0.001）。
腮腺 DKI 参数在诊断 SS 中具有很大的潜力，特别是在没有 MRI 形态学改变的早期 SS。
2 技术疗效：阶段 2 J. 磁共振成像 2017；46：1409-1417。
