7特斯拉对比增强磁共振肾血管造影：我们需要多少钆对比剂？

Contrast enhanced renal MR angiography at 7 Tesla: How much gadolinium do we need?

作者信息

Beiderwellen Karsten, Kraff Oliver, Laader Anja, Maderwald Stefan, Orzada Stephan, Ladd Mark E, Forsting Michael, Lauenstein Thomas C, Umutlu Lale

机构信息

Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany; Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany.

Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany.

出版信息

Eur J Radiol. 2017 Jan;86:76-82. doi: 10.1016/j.ejrad.2016.11.007. Epub 2016 Nov 5.

DOI:10.1016/j.ejrad.2016.11.007

PMID:28027770

Abstract

OBJECTIVES

To investigate whether a dose reduction of Gadobutrol for renal magnetic resonance angiography (MRA) at 7 Tesla (T) is feasible while preserving diagnostic image quality.

METHODS

Ten healthy volunteers were enrolled for a renal MRA on a 7T scanner. Fast low angle shot (FLASH) MRA data sets were obtained utilizing three different doses of Gadobutrol (0.1, 0.05 and 0.025mmol/kg body weight [BW]). Contrast ratios (CR) were measured in the aorta as well as in the intra- and extraparenchymal arteries compared to the psoas muscle. Qualitative analysis regarding the delineation of vessel structures was performed using a four-point-scale.

RESULTS

All doses of Gadobutrol allowed for a good delineation of the aorta and renal arteries. For the extra- and intraparenchymal segmental arteries higher values were observed for full and half dose in comparison to quarter dose. No significant difference was observed for full and half dose. A lower CR was observed for quarter compared to half dose (p<0.05) for the renal arteries.

CONCLUSIONS

While best results were observed for half and full dose, a dose reduction to 0.025mmol/kg BW is justifiable, maintaining a diagnostic image quality. This may be of high interest considering patients with renal impairment.

摘要