Beiderwellen Karsten, Kraff Oliver, Laader Anja, Maderwald Stefan, Orzada Stephan, Ladd Mark E, Forsting Michael, Lauenstein Thomas C, Umutlu Lale
Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany; Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany.
Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany.
Eur J Radiol. 2017 Jan;86:76-82. doi: 10.1016/j.ejrad.2016.11.007. Epub 2016 Nov 5.
To investigate whether a dose reduction of Gadobutrol for renal magnetic resonance angiography (MRA) at 7 Tesla (T) is feasible while preserving diagnostic image quality.
Ten healthy volunteers were enrolled for a renal MRA on a 7T scanner. Fast low angle shot (FLASH) MRA data sets were obtained utilizing three different doses of Gadobutrol (0.1, 0.05 and 0.025mmol/kg body weight [BW]). Contrast ratios (CR) were measured in the aorta as well as in the intra- and extraparenchymal arteries compared to the psoas muscle. Qualitative analysis regarding the delineation of vessel structures was performed using a four-point-scale.
All doses of Gadobutrol allowed for a good delineation of the aorta and renal arteries. For the extra- and intraparenchymal segmental arteries higher values were observed for full and half dose in comparison to quarter dose. No significant difference was observed for full and half dose. A lower CR was observed for quarter compared to half dose (p<0.05) for the renal arteries.
While best results were observed for half and full dose, a dose reduction to 0.025mmol/kg BW is justifiable, maintaining a diagnostic image quality. This may be of high interest considering patients with renal impairment.
研究在7特斯拉（T）场强下进行肾脏磁共振血管造影（MRA）时，降低钆布醇剂量同时保持诊断图像质量是否可行。
招募10名健康志愿者，在7T扫描仪上进行肾脏MRA检查。使用三种不同剂量的钆布醇（0.1、0.05和0.025mmol/kg体重[BW]）获取快速低角度激发（FLASH）MRA数据集。测量主动脉以及肾实质内和肾实质外动脉与腰大肌相比的对比率（CR）。使用四点量表对血管结构的描绘进行定性分析。
所有剂量的钆布醇都能很好地描绘主动脉和肾动脉。与四分之一剂量相比，全剂量和半剂量时肾实质外和肾实质内节段动脉的值更高。全剂量和半剂量之间未观察到显著差异。肾动脉的四分之一剂量与半剂量相比，CR较低（p<0.05）。
虽然全剂量和半剂量观察到最佳结果，但将剂量降低至0.025mmol/kg BW是合理的，可保持诊断图像质量。对于肾功能损害患者而言，这可能具有重要意义。
