Pal Shweta, Gupta Mohan Lal
Department of Pathology, Rabindra Nath Tagore (RNT) Medical College, Udaipur, Rajasthan, India.
Department of Pathology, Geetanjali Medical College, Udaipur, Rajasthan, India.
J Cytol. 2016 Oct-Dec;33(4):182-186. doi: 10.4103/0970-9371.190449.
Assigning grade to breast cancer on FNAC provides prognostic information and guides optimal therapy.
The present study was undertaken to grade breast carcinoma on cytology by Robinson's grading system and correlate it with Elstons modified Bloom Richardson histological grading system.
It is a prospective study done on fifty cases of breast cancer reported on cytology.
Fifty patients who underwent FNAC and mastectomy for breast carcinoma were cytologically and histologically graded. Correlation between cytological and histological grading system was determined. Sensitivity and specificity of Robinson's cytological grading system was calculated in each grade. All cases evaluated for presence of metastasis to axillary lymph nodes.
Correlation between cytological and histological grading was established using the non parametric Spearman†s correlation coefficient.
Concordance rate between cytological and histological grade was 78%. The coefficient of correlation between cytological grade and histological grade was 0.804 and value was <0.001 which indicated a strong correlation and significant association between the cytological and histological grade. Sensitivity was maximum in cytological grade I tumors (100%) and least in cytological grade III tumors (45.45%). Specificity was maximum in cytological grade III tumors (94.87%) and least in cytological grade II tumors (72.72%). The incidence of axillary lymph node metastasis was maximum in cytological grade III tumors and grade I tumors.
Cytological grade strongly predicts histological grade and is useful in selecting neoadjuvant chemotherapy.
在细针穿刺抽吸活检（FNAC）中对乳腺癌进行分级可提供预后信息并指导最佳治疗。
本研究旨在通过罗宾逊分级系统对乳腺癌进行细胞学分级，并将其与埃尔斯顿改良的布鲁姆 - 理查森组织学分级系统相关联。
这是一项对50例经细胞学报告的乳腺癌病例进行的前瞻性研究。
对50例行乳腺癌FNAC和乳房切除术的患者进行细胞学和组织学分级。确定细胞学和组织学分级系统之间的相关性。计算罗宾逊细胞学分级系统在每个级别中的敏感性和特异性。评估所有病例腋窝淋巴结转移情况。
使用非参数斯皮尔曼相关系数建立细胞学和组织学分级之间的相关性。
细胞学和组织学分级的一致性率为78%。细胞学分级与组织学分级之间的相关系数为0.804，P值<0.001，表明细胞学和组织学分级之间存在强相关性和显著关联。细胞学I级肿瘤的敏感性最高（100%），细胞学III级肿瘤的敏感性最低（45.45%）。细胞学III级肿瘤的特异性最高（94.87%），细胞学II级肿瘤的特异性最低（72.72%）。腋窝淋巴结转移发生率在细胞学III级肿瘤和I级肿瘤中最高。
细胞学分级能有力地预测组织学分级，有助于选择新辅助化疗。
