Wang YaDong, Chandler Christopher
Department of Biological Sciences, State University of New York at Oswego, Oswego, NY, United States; Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY, United States.
Department of Biological Sciences, State University of New York at Oswego , Oswego , NY , United States.
PeerJ. 2016 Dec 21;4:e2806. doi: 10.7717/peerj.2806. eCollection 2016.
The bacterial genus belongs to the order Legionellales in the Gammaproteobacteria, and consists of several described species and pathotypes, most of which are considered to be intracellular pathogens infecting arthropods. Two members of this genus, and , are known to infect terrestrial isopod crustaceans. In this study, we assembled a draft genomic sequence for , and performed a comparative genomic analysis with . We found evidence for several candidate genomic island regions in , none of which appear in the previously available genome sequenceFurthermore, one of these genomic island candidates in contained a gene that encodes a cytotoxin partially homologous to those found in and (Enterobacteriaceae), suggesting that horizontal gene transfer may have played a role in the evolution of pathogenicity in . These results lay the groundwork for future studies on the mechanisms underlying pathogenesis in , and this system may provide a good model for studying the evolution of host-microbe interactions in nature.
该细菌属属于γ-变形菌纲军团菌目，由几个已描述的物种和致病型组成，其中大多数被认为是感染节肢动物的细胞内病原体。已知该属的两个成员，即[具体菌名1]和[具体菌名2]，可感染陆生等足类甲壳动物。在本研究中，我们组装了[具体菌名1]的基因组序列草图，并与[具体菌名2]进行了比较基因组分析。我们在[具体菌名1]中发现了几个候选基因组岛区域的证据，而在先前可用的[具体菌名2]基因组序列中均未出现。此外，[具体菌名1]中的这些基因组岛候选区域之一包含一个基因，该基因编码一种细胞毒素，与[其他菌名]（肠杆菌科）中发现的细胞毒素部分同源，这表明水平基因转移可能在[具体菌名1]致病性的进化中发挥了作用。这些结果为未来研究[具体菌名1]发病机制奠定了基础，并且该系统可能为研究自然界中宿主-微生物相互作用的进化提供一个良好的模型。
