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从急性早幼粒细胞白血病的传统治疗到基于微小RNA的治疗

From conventional therapy toward microRNA-based therapy in acute promyelocytic leukemia.

作者信息

Ehtesham Naeim, Sharifi Mohammadreza

机构信息

Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

Adv Biomed Res. 2016 Nov 28;5:187. doi: 10.4103/2277-9175.190996. eCollection 2016.

DOI:10.4103/2277-9175.190996
PMID:28028527
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5156975/
Abstract

Acute promyelocytic leukemia (APL) is a hematopoietic malignancy that is known with its special cytogenetic feature. Several studies have surveyed expression signature of microRNAs (miRNAs) in APL patients, especially patients who are treated with conventional therapy of this disease. Using miRNAs as diagnostic or prognostic biomarkers in various cancers has been widely studied. Currently, most studies are focusing on exploiting miRNAs as therapeutic tools, and promising progress has been achieved in this field. Recently, studies in the field of miRNA-based therapy in APL have been started.

摘要

急性早幼粒细胞白血病（APL）是一种具有特殊细胞遗传学特征的造血系统恶性肿瘤。多项研究调查了APL患者，尤其是接受该疾病传统治疗的患者中微小RNA（miRNA）的表达特征。在各种癌症中使用miRNA作为诊断或预后生物标志物已得到广泛研究。目前，大多数研究集中于将miRNA开发为治疗工具，并且在该领域已取得了有前景的进展。最近，APL中基于miRNA治疗领域的研究已经展开。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f974/5156975/7d5b0a46ba4f/ABR-5-187-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f974/5156975/7d5b0a46ba4f/ABR-5-187-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f974/5156975/7d5b0a46ba4f/ABR-5-187-g001.jpg

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