Yazdani Mohamadreza, Aramesh Amirhossein, Rafiei Rahmatollah, Daghaghzadeh Hamed, Adibi Peyman
Department of Infectious Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Internal Medicine, School of Medicine, Islamic University, Najafabad Branch, Isfahan, Iran.
Adv Biomed Res. 2016 Nov 28;5:188. doi: 10.4103/2277-9175.192737. eCollection 2016.
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder. Recent studies suggest the importance of gut flora in the pathophysiology of it. Therefore, antibiotics have demonstrated a substantial benefit to reduce gut flora. Having few side effects, and applying one-dose per day, we studied the effect of azithromycin to treat IBS.
One hundred and twenty-six patients enrolled a randomized, double-blind, placebo-controlled study. The treatment group received azithromycin in addition to common treatment. Patients were followed for 12 weeks. Patients completed daily diaries documenting their symptoms.
One hundred and thirteen patients completed the study. The onset of relief occurred significantly sooner, and duration of relief was significantly longer in azithromycin group. Movement, abdominal pain, bloating, and gas were significantly better in azithromycin group. Monthly results showed superior relief in bloating, gas, overall symptom, and overall bloating during 3 months. Significantly more patients in azithromycin group felt relief in bloating and gas and had greater consistency relief in almost all weeks.
In our study, azithromycin significantly relieved most symptoms, such as abdominal pain, bloating, and gas. Overall symptom and overall bloating were relieved significantly in more patients in the intervention group in all weeks.
肠易激综合征（IBS）是一种常见的胃肠道疾病。最近的研究表明肠道菌群在其病理生理学中具有重要意义。因此，抗生素已被证明对减少肠道菌群有显著益处。由于副作用少且每日服用一剂，我们研究了阿奇霉素治疗IBS的效果。
126例患者参加了一项随机、双盲、安慰剂对照研究。治疗组在常规治疗的基础上接受阿奇霉素治疗。对患者进行了12周的随访。患者完成每日症状记录日记。
113例患者完成了研究。阿奇霉素组症状缓解的起效时间明显更早，缓解持续时间明显更长。阿奇霉素组的排便、腹痛、腹胀和气体症状明显改善。月度结果显示，在3个月内，阿奇霉素组在腹胀、气体、总体症状和总体腹胀方面的缓解效果更好。阿奇霉素组中，明显更多的患者在腹胀和气体方面感到缓解，并且在几乎所有周内缓解的一致性更高。
在我们的研究中，阿奇霉素显著缓解了大多数症状，如腹痛、腹胀和气体。在所有周内，干预组中更多患者的总体症状和总体腹胀得到了显著缓解。
