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CT引导下微波消融治疗骨样骨瘤的前瞻性初步研究。

Prospective pilot study of CT-guided microwave ablation in the treatment of osteoid osteomas.

作者信息

Prud'homme Clara, Nueffer Jean-Philippe, Runge Michel, Dubut Jonathan, Kastler Bruno, Aubry Sébastien

机构信息

Department of Musculoskeletal Imaging, University Hospital of Besancon, 25000, Besancon, France.

I4S Laboratory, INSERM EA4268, University of Franche-Comte, 25000, Besancon, France.

出版信息

Skeletal Radiol. 2017 Mar;46(3):315-323. doi: 10.1007/s00256-016-2558-5. Epub 2016 Dec 27.

Abstract

PURPOSE

The aims of this work were to assess the feasibility and efficacy of CT-guided microwave ablation (MWA) in the treatment of osteoid osteomas (OOs).

MATERIALS AND METHODS

Thirteen consecutive patients (range 11-31 years old) presenting with OO were prospectively included and treated by CT-guided MWA. Power and duration of MWA were both recorded. The patient's pain was assessed using a numeric pain rating scale (NRS), and side effects were recorded during procedures, after 1 day, 7 days and 1 month. The nidus vascularization and the volume of necrosis induced by MWA were assessed using contrast-enhanced MRI. Success was defined as the complete relief of the patient's pain 1 month after the first procedure, associated with necrosis of the nidus on follow-up MRI.

RESULTS

The success rate was up to 92.3% (12/13). At 1 day, 7 days and 1 month, the median NRSs were respectively 5 [interquartile range (IQR) 2-5], 0 (IQR 0-1) and 0 (IQR 0-0). Side effects observed were one partial and self-resolving lesion of a sensory branch of the radial nerve and two skin burns. The median power of the MWA used was 60 W (IQR 50-60) with a 1.5-min duration (IQR 1-2), leading to MWA-induced necrosis measuring on average 23 × 15 × 16 mm.

CONCLUSION

CT-guided MWA of OO has a success rate that appears to be almost similar to that of laser or radiofrequency ablation, but care must be taken to prevent nerve or skin lesions.

摘要

目的

本研究旨在评估CT引导下微波消融(MWA)治疗骨样骨瘤(OO)的可行性和疗效。

材料与方法

前瞻性纳入13例连续的骨样骨瘤患者(年龄范围11 - 31岁),并采用CT引导下MWA进行治疗。记录MWA的功率和持续时间。使用数字疼痛评分量表(NRS)评估患者的疼痛情况,并在操作过程中、术后1天、7天和1个月记录副作用。采用对比增强MRI评估MWA诱导的瘤巢血管化和坏死体积。成功定义为首次治疗后1个月患者疼痛完全缓解,且随访MRI显示瘤巢坏死。

结果

成功率高达92.3%(12/13)。术后1天、7天和1个月时,NRS中位数分别为5[四分位间距(IQR)2 - 5]、0(IQR 0 - 1)和0(IQR 0 - 0)。观察到的副作用包括1例桡神经感觉支部分性且可自行缓解的损伤和2例皮肤烧伤。所用MWA的中位功率为60W(IQR 50 - 60),持续时间为1.5分钟(IQR 1 - 2),导致MWA诱导的坏死平均大小为23×15×16mm。

结论

CT引导下MWA治疗骨样骨瘤的成功率似乎与激光或射频消融相近,但必须注意预防神经或皮肤损伤。

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