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经皮射频消融治疗儿童和成人类骨细胞瘤:92例患者的比较分析

Percutaneous Radiofrequency Ablation for the Treatment of Osteoid Osteoma in Children and Adults: A Comparative Analysis in 92 Patients.

作者信息

Hage Anthony N, Chick Jeffrey Forris Beecham, Gemmete Joseph J, Grove Jason J, Srinivasa Ravi N

机构信息

Division of Vascular and Interventional Radiology, Department of Radiology, University of Michigan Health Systems, Michigan Medicine, 1500 East Medical Center Drive, Ann Arbor, MI, 48109, USA.

出版信息

Cardiovasc Intervent Radiol. 2018 Sep;41(9):1384-1390. doi: 10.1007/s00270-018-1947-7. Epub 2018 Apr 12.

Abstract

PURPOSE

To compare technical success, complications, and long-term clinical success following radiofrequency ablation of osteoid osteomas in pediatric and adult patients.

MATERIALS AND METHODS

Ninety-two patients underwent percutaneous computed tomography-guided radiofrequency ablation for osteoid osteomas including 54 pediatric (mean age 12.9 years) and 38 adult (mean age 24.1 years) patients. Presenting indication, osteoma location, ablation method, technical success, complications, visual analog score, radiographic follow-up, clinical success, reintervention rate, and total follow-up were reported. Technical success was defined as placement of the probe in the radiolucent nidus with ablation. Clinical success was defined as resolution of symptoms.

RESULTS

Ablation indications included: pain localized to the lesion, night pain, and an osteoma on imaging in all patients. Majority of osteoid osteomas were localized to the femur (pediatric [n = 22, 40.7%]; adult [n = 12, 34.2%]) and tibia (pediatric [n = 21, 38.9%]; adult [n = 10, 26.3%]). Mean lesion size was 9.6 mm in pediatric patients and 9.0 mm in adults. Technical success was achieved in all pediatric patients (100%) and 97.4% of adults. Two complications occurred. Primary clinical success was achieved in 49 (90.7%) pediatric and 35 (92.1%) adult patients. Five (9.3%) pediatric and 3 (7.9%) adult patients sought reintervention for residual symptoms, and all had secondary clinical success. Mean total follow-up was 95.2 ± 58.7 months in pediatric and 90.0 ± 61.6 months in adult patients. No differences in outcomes were identified between pediatric and adult patients.

CONCLUSION

Radiofrequency ablation of osteoid osteomas is safe with excellent technical and clinical success rates in pediatric and adult patients.

摘要

目的

比较儿童和成人患者骨样骨瘤射频消融后的技术成功率、并发症及长期临床成功率。

材料与方法

92例患者接受了经皮计算机断层扫描引导下的骨样骨瘤射频消融术,其中包括54例儿童患者(平均年龄12.9岁)和38例成人患者(平均年龄24.1岁)。报告了就诊指征、骨瘤位置、消融方法、技术成功率、并发症、视觉模拟评分、影像学随访、临床成功率、再次干预率及总随访情况。技术成功定义为将探头置于透光瘤巢并进行消融。临床成功定义为症状缓解。

结果

所有患者的消融指征包括:病变部位疼痛、夜间疼痛及影像学检查发现骨瘤。大多数骨样骨瘤位于股骨(儿童患者[n = 22,40.7%];成人患者[n = 12,34.2%])和胫骨(儿童患者[n = 21,38.9%];成人患者[n = 10,26.3%])。儿童患者平均病变大小为9.6 mm,成人患者为9.0 mm。所有儿童患者(100%)和97.4%的成人患者实现了技术成功。发生了2例并发症。49例(90.7%)儿童患者和35例(92.1%)成人患者获得了初次临床成功。5例(9.3%)儿童患者和3例(7.9%)成人患者因残留症状寻求再次干预,均获得了二次临床成功。儿童患者平均总随访时间为95.2±58.7个月,成人患者为90.0±61.6个月。未发现儿童和成人患者在结局方面存在差异。

结论

骨样骨瘤的射频消融术是安全的,在儿童和成人患者中技术成功率和临床成功率均很高。

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