Unriza-Puin Sonia, Bautista-Molano Wilson, Lafaurie Gloria I, Valle-Oñate Rafael, Chalem Philippe, Chila-Moreno Lorena, Bello-Gualtero Juan Manuel, Romero-Sánchez Consuelo
Unit of Oral Basic Investigation, School of Dentistry, Universidad El Bosque, Av. Cra 9 # 131A 02, Bogotá, Colombia.
School of Medicine, Universidad Militar Nueva Granada, Cra 5 # 49 00, Third Floor, Bogotá, Colombia.
Clin Rheumatol. 2017 Apr;36(4):799-806. doi: 10.1007/s10067-016-3519-z. Epub 2016 Dec 28.
The aim of this study was to investigate the body mass index (BMI), anti-citrullinated protein antibodies (ACPAs) status and the presence of periodontitis and IgG-1/IgG-2 antibodies against Porphyromonas gingivalis (Pg) in the first-degree relatives (FDRs) of rheumatoid arthritis (RA) patients and compare these variables with a control group of healthy individuals from the general population. In total, 100 FDR individuals and 200 healthy controls matched by age and gender were included. Rheumatologic and periodontal assessment was performed, and the presence of ACPAs and anti-P. gingivalis antibodies was evaluated. Groupwise comparisons were analysed using the McNemar and Wilcoxon tests. A conditional logistic regression analysis was performed to establish the associations between BMI, ACPAs and periodontitis in both groups. In the FDR group, 70% of the subjects were female, with a mean age of 37.3 ± 13 years. Obesity was observed in 17 and 7% of the FDRs and controls, respectively. ACPAs were found in 7% of the FDRs vs. 2.5% of the controls. Periodontitis was diagnosed in 79 and 56% of the FDRs and controls, respectively. Among the FDRs, 15% had severe periodontitis. There were associations in the FDR group related to the presence of obesity (OR 2.93, 95% CI 1.03-8.28), ACPAs (OR 2.45, 95% CI 0.7-8.32) and periodontitis (OR 3.70 95% CI 1.89-7.29). Regarding anti-P. gingivalis antibodies and smoking history, no differences were found between the groups. Obesity, ACPAs and periodontitis (diagnosis and severity) can be considered as relevant conditions associated with the development of RA in FDRs.
本研究旨在调查类风湿关节炎（RA）患者的一级亲属（FDRs）的体重指数（BMI）、抗瓜氨酸化蛋白抗体（ACPAs）状态、牙周炎的存在情况以及针对牙龈卟啉单胞菌（Pg）的IgG-1/IgG-2抗体，并将这些变量与来自普通人群的健康个体对照组进行比较。总共纳入了100名FDR个体和200名年龄和性别匹配的健康对照。进行了风湿病学和牙周评估，并评估了ACPAs和抗牙龈卟啉单胞菌抗体的存在情况。使用McNemar检验和Wilcoxon检验进行组间比较。进行了条件逻辑回归分析以确定两组中BMI、ACPAs和牙周炎之间的关联。在FDR组中，70%的受试者为女性，平均年龄为37.3±13岁。FDR组和对照组中肥胖的发生率分别为17%和7%。FDR组中7%的人检测到ACPAs，而对照组为2.5%。FDR组和对照组中分别有79%和56%被诊断为牙周炎。在FDR组中，15%患有重度牙周炎。FDR组中存在与肥胖（OR 2.93，95%CI 1.03 - 8.28）、ACPAs（OR 2.45，95%CI 0.7 - 8.32）和牙周炎（OR 3.70，95%CI 1.89 - 7.29）相关的关联。关于抗牙龈卟啉单胞菌抗体和吸烟史，两组之间未发现差异。肥胖、ACPAs和牙周炎（诊断和严重程度）可被视为与FDRs中RA发生相关的相关情况。
