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老年人维生素D缺乏及其相关因素:墨西哥健康与老龄化研究的横断面分析

Vitamin D deficiency in older adults and its associated factors: a cross-sectional analysis of the Mexican Health and Aging Study.

作者信息

Carrillo-Vega María Fernanda, García-Peña Carmen, Gutiérrez-Robledo Luis Miguel, Pérez-Zepeda Mario Ulises

机构信息

Geriatric Epidemiology Unit, Research Department at the Instituto Nacional de Geriatría, Periférico Sur 2767, Colonia San Jerónimo Lídice, Delegación Magdalena Contreras, código postal 10200, Mexico.

Head of the Research Office, Instituto Nacional de Geriatría, Periférico Sur 2767, Colonia San Jerónimo Lídice, Delegación Magdalena Contreras, Código postal 10200, Mexico.

出版信息

Arch Osteoporos. 2017 Dec;12(1):8. doi: 10.1007/s11657-016-0297-9. Epub 2016 Dec 27.

Abstract

UNLABELLED

Vitamin D deficiency was common in older adults from a country with adequate sun exposure. The variables associated with this deficiency provide insight into the next steps needed to characterize older adults with this deficiency and to treat it accordingly.

PURPOSE

The aim of this study was to describe the prevalence of and factors associated with vitamin D deficiency among Mexican older adults.

METHODS

This was a secondary analysis of the last wave of the Mexican Health and Aging Study. Vitamin D levels along with other biomarkers were obtained from a sub-sample of Mexican adults older than 60 years. Prevalence was described by sex and age group, and a multivariate analysis was performed to test the factors associated with this condition.

RESULTS

Data from 1088 adults over the age of 60 years were analyzed. The mean serum vitamin D level was 23.1 ± 8.1 ng/mL and was significantly higher among men than women (25.6 ± 0.6 and 22.8 ± 0.5 ng/mL, respectively; p < 0.001). In total, 37.3% (n = 406) presented with vitamin D deficiency, 65% of whom were women. Low 25-(OH)-vitamin D levels were associated with female sex (OR 1.74, 95% CI 1.59-2.42), current smoking (OR 2.21, 95% CI 1.47-3.39), education (OR 1.1, 95% CI 1.06-1.13), physical activity (OR 1.74, 95% CI 1.31-2.23), and high levels of glycated hemoglobin (OR 1.16, 95% CI 1.07-1.25).

CONCLUSIONS

Vitamin D deficiency was highly prevalent in Mexican older adults and was associated with a number of factors, indicating the multifactorial causality of this deficiency.

摘要

未标注

在一个阳光充足的国家,老年人维生素D缺乏情况普遍。与这种缺乏相关的变量有助于了解识别患有维生素D缺乏症的老年人并进行相应治疗所需的后续步骤。

目的

本研究旨在描述墨西哥老年人维生素D缺乏的患病率及其相关因素。

方法

这是对墨西哥健康与老龄化研究最后一波数据的二次分析。从60岁以上的墨西哥成年人子样本中获取维生素D水平及其他生物标志物。按性别和年龄组描述患病率,并进行多变量分析以检验与这种情况相关的因素。

结果

分析了1088名60岁以上成年人的数据。血清维生素D平均水平为23.1±8.1 ng/mL,男性显著高于女性(分别为25.6±0.6和22.8±0.5 ng/mL;p<0.001)。共有37.3%(n = 406)存在维生素D缺乏,其中65%为女性。低25-(OH)-维生素D水平与女性性别(比值比1.74,95%置信区间1.59 - 2.42)、当前吸烟(比值比2.21,95%置信区间1.47 - 3.39)、教育程度(比值比1.1,95%置信区间1.06 - 1.13)、身体活动(比值比1.74,95%置信区间1.31 - 2.23)以及高糖化血红蛋白水平(比值比1.16,95%置信区间1.07 - 1.25)相关。

结论

维生素D缺乏在墨西哥老年人中非常普遍,且与多种因素相关,表明这种缺乏具有多因素因果关系。

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