Hirani Vasant, Cumming Robert G, Le Couteur David G, Naganathan Vasikaran, Blyth Fiona, Handelsman David J, Waite Louise M, Seibel Markus J
Centre for Education and Research on Ageing, University of Sydney, Sydney, New South Wales, Australia; School of Public Health, University of Sydney, Sydney, New South Wales, Australia; ARC Centre of Excellence in Population Ageing Research, University of Sydney, Sydney, New South Wales, Australia.
J Am Geriatr Soc. 2014 Sep;62(9):1741-7. doi: 10.1111/jgs.12975. Epub 2014 Aug 12.
To examine the associations between serum 25-hydroxyvitamin D (25OHD) levels and the active vitamin D metabolite, 1,25-hydroxyvitamin D (1,25OHD), with type 2 diabetes mellitus (DM) in community-living men aged 70 and older.
Cross-sectional.
A population-based, cross-sectional analysis of the baseline phase of the Concord Health and Ageing in Men Project (CHAMP), a large epidemiological study conducted in Sydney between January 2005 and May 2007.
Community dwelling men aged 70 and older taking part in CHAMP (N = 1,659).
Serum 25OHD and 1,25OHD levels, presence of DM, age, country of birth, season of blood collection, sun exposure, body mass index, vitamin D supplement use, statin use, income, measures of health, depression, activity of daily living disabilities, parathyroid hormone, estimated glomerular filtration rate, phosphate, and calcium.
The prevalence of DM was 20.0%. There was a significant association between low 25OHD and 1,25OHD levels and DM that remained after adjustment for a wide range of confounders and covariates of clinical significance such as comorbidity, renal function, calciotropic hormones, and medications.
25OHD and 1,25OHD levels were associated with DM. The independent association between serum 25OHD and 1,25OHD concentrations and DM raises the question of whether each of the two vitamin D metabolites may influence DM through different biological mechanisms and pathways.
研究70岁及以上社区居住男性血清25-羟维生素D（25OHD）水平和活性维生素D代谢产物1,25-二羟维生素D（1,25OHD）与2型糖尿病（DM）之间的关联。
横断面研究。
基于人群的横断面分析，来自康科德男性健康与老龄化项目（CHAMP）基线阶段，这是一项于2005年1月至2007年5月在悉尼进行的大型流行病学研究。
参与CHAMP的70岁及以上社区居住男性（N = 1659）。
血清25OHD和1,25OHD水平、DM的存在情况、年龄、出生国家、采血季节、阳光暴露、体重指数、维生素D补充剂使用情况、他汀类药物使用情况、收入、健康指标、抑郁、日常生活活动能力障碍、甲状旁腺激素、估计肾小球滤过率、磷酸盐和钙。
DM的患病率为20.０%。低25OHD和1,25OHD水平与DM之间存在显著关联，在对一系列具有临床意义的混杂因素和协变量（如合并症、肾功能、钙调节激素和药物）进行调整后，该关联仍然存在。
25OHD和1,25OHD水平与DM相关。血清25OHD和1,25OHD浓度与DM之间的独立关联提出了一个问题，即这两种维生素D代谢产物是否可能通过不同的生物学机制和途径影响DM。
