Jensen Annette Klüver, Macklon Kirsten Tryde, Fedder Jens, Ernst Erik, Humaidan Peter, Andersen Claus Yding
The Laboratory of Reproductive Biology, Section 5712, Juliane Marie Centre for Women, Children and Reproduction, University Hospital of Copenhagen, University of Copenhagen, Blegdamsvej 9, Rigshospitalet, DK-2100, Copenhagen, Denmark.
The Fertility Clinic, The Juliane Marie Centre, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark.
J Assist Reprod Genet. 2017 Mar;34(3):325-336. doi: 10.1007/s10815-016-0843-9. Epub 2016 Dec 27.
This study aims to make an account of the children born following transplantation of frozen-thawed ovarian tissue worldwide with specific focus on the perinatal outcome of the children. Furthermore, perinatal outcome of seven deliveries (nine children) from Denmark is reported.
PubMed was searched for papers of deliveries resulting from ovarian tissue cryopreservation (OTC). Seven women underwent OTC prior to chemotherapy. Four of these women still had low ovarian function and had tried to conceive. They therefore had tissue autotransplanted to augment their fertility. The other three women had developed premature ovarian insufficiency (POI) after the end of treatment.
Worldwide, approximately 95 children have been born or will be born in the near future from OTC, including these 9 new children. Information on the perinatal outcome was found on 40 children. The mean gestational age was 39 weeks and the mean birth weight was 3168 g of the singleton pregnancies, which is within internationally recognized normal standards. Furthermore, half the singletons resulted from natural conception and all twins resulted from in vitro fertilization treatment. All seven Danish women became pregnant within 1-3 years after transplantation. They gave birth to nine healthy children.
The data is reassuring and further suggests that cryopreservation of ovarian tissue is becoming an established fertility preservation method. The seven Danish women reported in this study were all in their early thirties when OTC was performed. Most other reported cases were in the women's twenties. This suggests that the follicular pool in the thirties is large enough and sufficient to sustain fertility.
本研究旨在统计全球范围内冻融卵巢组织移植后出生的儿童情况，并特别关注这些儿童的围产期结局。此外，还报告了丹麦7例分娩（9名儿童）的围产期结局。
在PubMed上检索有关卵巢组织冷冻保存（OTC）后分娩的论文。7名女性在化疗前接受了OTC。其中4名女性卵巢功能仍然低下并尝试受孕，因此进行了组织自体移植以提高生育能力。另外3名女性在治疗结束后出现了卵巢早衰（POI）。
在全球范围内，约有95名儿童已出生或在不久的将来即将出生于OTC，包括这9名新出生的儿童。有40名儿童的围产期结局信息。单胎妊娠的平均孕周为39周，平均出生体重为3168克，处于国际公认的正常标准范围内。此外，一半的单胎是自然受孕，所有双胞胎均来自体外受精治疗。所有7名丹麦女性在移植后1至3年内怀孕，她们生下了9名健康儿童。
这些数据令人安心，并进一步表明卵巢组织冷冻保存正在成为一种成熟的生育力保存方法。本研究中报告的7名丹麦女性在进行OTC时均为30岁出头。其他大多数报告的病例是20多岁的女性。这表明30多岁时的卵泡池足够大，足以维持生育能力。
