Stamp L A, Young H M
Department of Anatomy & Neuroscience, University of Melbourne, Parkville, Vic., Australia.
Neurogastroenterol Motil. 2017 Jan;29(1). doi: 10.1111/nmo.12993.
As current options for treating most enteric neuropathies are either non-effective or associated with significant ongoing problems, cell therapy is a potential attractive possibility to treat congenital and acquired neuropathies. Studies using animal models have shown that following transplantation of enteric neural progenitors into the bowel of recipients, the transplanted cells migrate, proliferate, and generate neurons that are electrically active and receive synaptic inputs. Recent studies have transplanted human enteric neural progenitors into the mouse colon and shown engraftment. In this article, we summarize the significance of these recent advances and discuss priorities for future research that might lead to the use of regenerative medicine to treat enteric neuropathies in the clinic.
由于目前治疗大多数肠道神经病变的方法要么无效，要么存在严重的持续问题，细胞疗法是治疗先天性和后天性神经病变的一种潜在的有吸引力的可能性。使用动物模型的研究表明，将肠道神经祖细胞移植到受体肠道后，移植的细胞会迁移、增殖，并产生具有电活性且能接收突触输入的神经元。最近的研究已将人类肠道神经祖细胞移植到小鼠结肠并显示出植入情况。在本文中，我们总结了这些最新进展的意义，并讨论了未来研究的重点，这些研究可能会促使再生医学在临床上用于治疗肠道神经病变。
