Deng Zhaomin, Yang Yuan, Huang Xiaojun, Kuang Yu, Qin Zhen, Wang Baoning, Wang Hongren, Li Mingyuan
Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University.
Adv Clin Exp Med. 2016 Nov-Dec;25(6):1165-1172. doi: 10.17219/acem/36603.
Lung cancer is the most common malignancy worldwide. A better understanding of the mechanisms may contribute to early diagnosis and establishment of new therapeutic targets.
A meta-analysis was performed to investigate the association of transforming growth factor-beta 1 (TGFβ1) T+869C and C-509T polymorphisms with lung cancer susceptibility.
Relevant studies were identified through PubMed, Medline, Embase and CNKI databases. The pooled odds ratios (ORs) with its 95% confidence intervals (CIs) were employed to assess these associations in a fixedor random-effects model.
For the TGFβ1 T+869C polymorphism, 5 published case-control studies with 1167 cases and 1365 controls were included. Overall, no significant association was found between the TGFβ1 T+869C polymorphism and lung cancer susceptibility under any genetic models in the total population (p > 0.05). A subgroup analysis by ethnicity showed no significant association among the Asian population as well, while a significant association was observed in Caucasian descendants. For the TGFβ1 C-509T polymorphism, 4 studies were considered, including 1029 cases and 1133 controls. However, this polymorphism also did not increase the risk of lung cancer in all genetic comparison models.
This meta-analysis suggests that TGFβ1 T+869C and C-509T polymorphisms may not contribute to lung cancer risk in the total population, while the T+869C polymorphism may increase the risk of lung cancer in the Caucasian population. However, many studies are still required to evaluate these associations in large populations.
肺癌是全球最常见的恶性肿瘤。更好地了解其发病机制可能有助于早期诊断并确立新的治疗靶点。
进行一项荟萃分析，以研究转化生长因子-β1（TGFβ1）T+869C和C-509T基因多态性与肺癌易感性之间的关联。
通过PubMed、Medline、Embase和中国知网数据库检索相关研究。采用合并比值比（OR）及其95%置信区间（CI），在固定效应或随机效应模型中评估这些关联。
对于TGFβ1 T+869C基因多态性，纳入了5项已发表的病例对照研究，共1167例病例和1365例对照。总体而言，在任何遗传模型下，TGFβ1 T+869C基因多态性与总人群肺癌易感性之间均未发现显著关联（p>0.05）。按种族进行的亚组分析显示，亚洲人群中也未发现显著关联，而在白种人后裔中观察到显著关联。对于TGFβ1 C-509T基因多态性，纳入了4项研究，共1029例病例和1133例对照。然而，在所有遗传比较模型中，该基因多态性也未增加肺癌风险。
这项荟萃分析表明，TGFβ1 T+869C和C-509T基因多态性可能与总人群肺癌风险无关，而T+869C基因多态性可能增加白种人群肺癌风险。然而，仍需要许多研究在大样本人群中评估这些关联。
