Noszczyk-Nowak Agnieszka, Cepiel Alicja, Janiszewski Adrian, Pasławski Robert, Gajek Jacek, Pasławska Urszula, Nicpoń Józef
Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Poland.
Center for Experimental Diagnostics and Biomedical Innovations, Wrocław, Poland.
Adv Clin Exp Med. 2016 Nov-Dec;25(6):1249-1254. doi: 10.17219/acem/65808.
Swine are a well-recognized animal model for human cardiovascular diseases. Despite the widespread use of porcine model in experimental electrophysiology, still no reference values for intracardiac electrical activity and conduction parameters determined during an invasive electrophysiology study (EPS) have been developed in this species thus far.
The aim of the study was to develop a set of normal values for intracardiac electrical activity and conduction parameters determined during an invasive EPS of swine.
The study included 36 healthy domestic swine (24-40 kg body weight). EPS was performed under a general anesthesia with midazolam, propofol and isoflurane. The reference values for intracardiac electrical activity and conduction parameters were calculated as arithmetic means ± 2 standard deviations.
The reference values were determined for AH, HV and PA intervals, interatrial conduction time at its own and imposed rhythm, sinus node recovery time (SNRT), corrected sinus node recovery time (CSNRT), anterograde and retrograde Wenckebach points, atrial, atrioventricular node and ventricular refractory periods. No significant correlations were found between body weight and heart rate of the examined pigs and their electrophysiological parameters.
The hereby presented reference values can be helpful in comparing the results of various studies, as well as in more accurately estimating the values of electrophysiological parameters that can be expected in a given experiment.
猪是一种公认的人类心血管疾病动物模型。尽管猪模型在实验电生理学中广泛应用，但迄今为止，尚未建立该物种在有创电生理研究（EPS）期间测定的心内电活动和传导参数的参考值。
本研究的目的是建立一组猪有创EPS期间测定的心内电活动和传导参数的正常值。
本研究纳入36头健康家猪（体重24 - 40千克）。在咪达唑仑、丙泊酚和异氟醚全身麻醉下进行EPS。心内电活动和传导参数的参考值计算为算术平均值±2个标准差。
确定了AH、HV和PA间期、自身及诱发节律下的房间传导时间、窦房结恢复时间（SNRT）、校正窦房结恢复时间（CSNRT）、顺行和逆行文氏点、心房、房室结和心室不应期的参考值。在所检查猪的体重、心率与其电生理参数之间未发现显著相关性。
本文提出的参考值有助于比较各种研究结果，以及更准确地估计给定实验中预期的电生理参数值。
