Sarrión Auñón J, Chorro Gascó F J, Negueruela Cardo A, Burguera Pérez M, Sanchis Forés J, Chuliá Campos V, Palanca Sanfrancisco J M, Such Belenguer L, López Merino V
Servicio de Anestesiología y Reanimación, Hospital Clínico Universitario, Valencia.
Rev Esp Cardiol. 1992 Aug-Sep;45(7):462-70.
In two groups, A and B, both composed of 10 mongrel dogs, we studied the cardiac electrophysiologic effects of 1 and 1.5 MAC isoflurane administered by liquid injection in a closed circuit. In group B the study was done under pharmacological autonomic blockade (AB). With electrode catheters for programmed pacing and endocavitary potential recordings, we determined during the anesthesia with 1 and 1.5 MAC isoflurane: RR, spontaneous and paced AH, and HV intervals, corrected sinus recovery time (CSRT), Wenckebach point (WP), functional and effective refractory periods of atria (AFRP, AERP) and AV node (AVNFRP, AVNERP), and ventricular effective refractory period (VERP), these were compared to the ones obtained with a previous thiopental control. In group A, 1 MAC isoflurane increased over control: AERP and AH interval (p < 0.05), AFRP (p < 0.005), RR and AH paced intervals, WP, AVNFRP and VERP (p < 0.001), adding to these CSRT (p < 0.01) in 1.5 CAM. This level did not show differences with 1 MAC. In group B, 1 MAC isoflurane increased over control: AH (p < 0.05), RR, paced AH intervals, WP and AVNFRP (p < 0.001), adding to these AFRP and AERP (p < 0.05) in 1.5 MAC. This level increased with regard to 1 MAC: AFRP, AERP, AH paced interval and AVNERP (p < 0.05), and AVNFRP (p < 0.005). Isoflurane alone or with AB increased parameters of sinusal automaticity, atrial refractoriness, AV nodal conduction and refractoriness, increasing only without AB ventricular refractoriness and CSRT. With AB atrial and AV nodal refractoriness increased in an anesthetic depth dependent way.
在A组和B组中，每组均由10只杂种犬组成，我们研究了通过在闭合回路中液体注射给予1和1.5 MAC异氟烷的心脏电生理效应。在B组中，研究是在药理学自主神经阻滞（AB）下进行的。使用用于程控起搏和心腔内电位记录的电极导管，我们在1和1.5 MAC异氟烷麻醉期间测定了：RR、自发和起搏的AH以及HV间期、校正窦房结恢复时间（CSRT）、文氏点（WP）、心房（AFRP、AERP）和房室结（AVNFRP、AVNERP）的功能和有效不应期以及心室有效不应期（VERP），并将这些结果与先前硫喷妥钠对照所获得的结果进行比较。在A组中，1 MAC异氟烷与对照相比增加了：AERP和AH间期（p<0.05）、AFRP（p<0.005）、RR和起搏的AH间期、WP、AVNFRP和VERP（p<0.001），在1.5 MAC时还增加了CSRT（p<0.01）。该水平与1 MAC时无差异。在B组中，1 MAC异氟烷与对照相比增加了：AH（p<0.05）、RR、起搏的AH间期、WP和AVNFRP（p<0.001），在1.5 MAC时还增加了AFRP和AERP（p<0.05）。该水平与1 MAC相比增加了：AFRP、AERP、起搏的AH间期和AVNERP（p<0.05）以及AVNFRP（p<0.005）。单独使用异氟烷或联合AB增加了窦性自律性、心房不应期、房室结传导和不应期的参数，仅在无AB时增加了心室不应期和CSRT。联合AB时，心房和房室结不应期以麻醉深度依赖的方式增加。
