Kuzan Aleksandra
Department of Medical Biochemistry, Wroclaw Medical University, Poland.
Adv Clin Exp Med. 2016 Nov-Dec;25(6):1331-1336. doi: 10.17219/acem/32026.
According to current data, the thymosin β family is composed of 20 short (40-44 amino acid) peptides, but in a healthy human body only 2 are expressed - thymosin β4 and β10. Their most characteristic feature is the ability to form a complex with monomeric actin, thereby preventing polymerization into a filamentous form, hence the name Actin-Binding Protein (ABP). These peptides play numerous different functions. Among others, they affect the processes of carcinogenesis, differentiation and angiogenesis, influence metalloproteinase activity and accelerate wound healing. Moreover, significant biological activity has also been displayed by Tβ4 derived peptides: Ac-SDKP, the N-terminal fragment which is involved, inter alia, in stimulating angiogenesis and the inhibition of stem cell proliferation and Tβ4 sulfoxide, an oxidation product of one of the peptide methionine by hydrogen peroxide, which inhibit the development of inflammation. The properties of these peptides have potential applications in cardiovascular medicine, dermatology, ophthalmology and other medical areas.
根据目前的数据，胸腺素β家族由20种短肽（40 - 44个氨基酸）组成，但在健康人体中仅表达2种——胸腺素β4和β10。它们最显著的特征是能够与单体肌动蛋白形成复合物，从而阻止其聚合成丝状形式，因此被称为肌动蛋白结合蛋白（ABP）。这些肽发挥着许多不同的功能。其中，它们影响致癌作用、分化和血管生成过程，影响金属蛋白酶活性并加速伤口愈合。此外，胸腺素β4衍生肽也表现出显著的生物活性：Ac - SDKP，其N端片段尤其参与刺激血管生成和抑制干细胞增殖；以及胸腺素β4亚砜，它是该肽的甲硫氨酸之一被过氧化氢氧化后的产物，可抑制炎症发展。这些肽的特性在心血管医学、皮肤病学、眼科和其他医学领域具有潜在应用。
